{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:29:04Z","timestamp":1747193344257,"version":"3.40.5"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Introduction:<\/i><\/b> Organ volumes at postmortem magnetic resonance imaging (PMMR) should reflect autopsy organ weights, and thus brain:liver volume ratios on imaging could be a surrogate for weight volume ratios at autopsy to indicate fetal growth restriction (FGR). This study aims to determine whether imaging-based organ volume ratios can replace autopsy organ weight ratios. <b><i>Materials and Meth<\/i><\/b> <b><i>ods:<\/i><\/b> An unselected cohort of perinatal deaths underwent PMMR prior to autopsy. Semiautomated brain and liver volumes were compared to autopsy organ weights and ratios. Ratios were compared using Bland-Altman plots, and intra- and interobserver variability was assessed. <b><i>Results:<\/i><\/b> A total 49 fetuses (25 male, 51%) at 17\u201342 weeks gestation were \u00adassessed. There was a reasonable correlation between autopsy-derived brain:liver weight ratios (AB:LwR) and imaging-derived brain:liver volume ratios (IB:LvR; <i>r<\/i> = 0.8). The mean difference between AB:LwR and IB:LvR was +0.7 (95% limits of agreement range \u20131.5 to +2.9). In a small subset where FGR was present, the optimal IB:LvR \u22655.5 gave 83.3% sensitivity and 86.0% specificity for diagnosis. There was acceptable agreement within readers (mean difference in IB:LvRs 0.77 \u00b1 2.21) and between readers \u20130.36 \u00b1 0.68. <b><i>Conclusion:<\/i><\/b> IB:LvR provides a surrogate evaluation of AB:LwRs, and may be used as a marker of FGR where autopsy is declined.<\/jats:p>","DOI":"10.1159\/000497158","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T21:00:27Z","timestamp":1554930027000},"page":"360-367","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility of Postmortem Imaging Assessment of Brain: Liver Volume Ratios with Pathological Validation"],"prefix":"10.1159","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-9967","authenticated-orcid":false,"given":"Susan\u00a0C.","family":"Shelmerdine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly\u00a0L.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u00a0C.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil\u00a0J.","family":"Sebire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen\u00a0J.","family":"Arthurs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-63"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4137\/CMPed.S40070"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1977.tb12550.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.16017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-009-1486-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.022483"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14600"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5043"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11151"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.10.007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.07.013"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.12.026"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5199"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-4057-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000188"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2015.04.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-7084-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14948"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:14:57Z","timestamp":1745424897000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,12,12]]},"published-print":{"date-parts":[[2019,12,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000497158","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2019]]}}}