{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:10:46Z","timestamp":1770819046890,"version":"3.50.1"},"reference-count":52,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Alzheimer\u2019s disease (AD) is a neurodegenerative disorder accounting for 60\u201370% of dementia cases. Genetic origin accounts for 49\u201379% of disease risk. This paper aims to investigate the association of 17 polymorphisms within 7 genes involved in neurotransmission (<i>COMT<\/i>, <i>HTR2A<\/i>, <i>PPP3CC<\/i>, <i>RORA<\/i>, <i>SIGMAR1<\/i>, <i>SIRT1<\/i>, and <i>SORBS3<\/i>) and AD. <b><i>Methods:<\/i><\/b> A Greek and an Italian sample were investigated, for a total of 156 AD subjects and 301 healthy controls. Exploratory analyses on psychosis and depression comorbidities were performed, as well as on other available clinical and serological parameters. <b><i>Results:<\/i><\/b> AD was associated with rs4680 within the <i>COMT<\/i> gene in the total sample. Trends of association were found in the 2 subsamples. Some nominal associations were found for the depressive phenotype. rs10997871 and rs10997875 within <i>SIRT1<\/i> were nominally associated with depression in the total sample and in the Greek subsample. rs174696 within <i>COMT<\/i> was associated with depression comorbidity in the Italian subsample. <b><i>Discussion:<\/i><\/b> Our data support the role of <i>COMT<\/i>, and particularly of rs4680, in the pathogenesis of AD. Furthermore, the <i>SIRT1<\/i> gene seems to modulate depressive symptomatology in the AD population.<\/jats:p>","DOI":"10.1159\/000497164","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T21:00:43Z","timestamp":1558645243000},"page":"79-85","source":"Crossref","is-referenced-by-count":12,"title":["Alzheimer\u2019s Disease and Neurotransmission Gene Variants: Focus on Their Effects on Psychiatric Comorbidities and Inflammatory Parameters"],"prefix":"10.1159","volume":"78","author":[{"given":"Stefano","family":"Porcelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Crisafulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonis","family":"Politis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Liappas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Albani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George\u00a0N.","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-3759","authenticated-orcid":false,"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2005.16.4.325"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.03.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299784"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/375754a0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638621"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/52A.2.M117"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/832379"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12108"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-73"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181c727f7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.01.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07101573"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-0946"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90038-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000313533"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.44.5.382"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000082660"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.149.6.698"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2012.08.015"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0027-10.2010"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04222.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9096-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116178"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.12.009"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/nature14659"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.01.009"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.01.043"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.04.003"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-017-0112-8"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.06.001"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8967"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00070-4"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.04.014"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1214546"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-11-0938"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122359"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-27069-2_1"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0745-y"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4202"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05300.x"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2576"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2009.5.3.120"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8459-x"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601758"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1159\/000446921"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00086"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2015-000017"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1632604.302"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.08.016"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.01.008"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:15:07Z","timestamp":1745424907000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,6,19]]},"published-print":{"date-parts":[[2019,6,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000497164","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}