{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:16:44Z","timestamp":1761581804654,"version":"3.40.5"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Up to 40% of patients with metastatic melanoma (MM) develop brain metastases. Radiotherapy (RT) may potentiate the effects of immunotherapy (IO), even on distant sites (&lt;i&gt;abscopal&lt;\/i&gt; effect). &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt;&lt;i&gt;&lt;\/i&gt; We retrospectively analyzed all our MM patients treated with IO within 6 months before\/after brain RT between 2012 and 2016. Progression-free (PFS) and overall survival (OS) were estimated with the Kaplan-Meier method and compared with those of controls treated with IO during the same period. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt;&lt;i&gt;&lt;\/i&gt; Thirty-six cases and 25 controls were identified. Among cases, 23 patients received an anti-CTLA4 agent and 13 an anti-PD1 agent. Eighteen cases were treated with stereotactic RT and 18 with whole-brain RT. Median PFS from the beginning of RT was 4 months in first-line and 2 months in second-line treatment. A third of the cases progressed at first evaluation after RT. Median OS from the beginning of RT was 7 months in first-line and 4 months in second-line treatment. Median PFS and OS of each treatment line showed a trend towards inferiority compared with those of controls. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Synergism between RT and IO was not observed in our case series. No cases of &lt;i&gt;abscopal&lt;\/i&gt; effect were seen, and most patients underwent early systemic progression after RT.<\/jats:p>","DOI":"10.1159\/000497211","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T22:01:49Z","timestamp":1551823309000},"page":"182-189","source":"Crossref","is-referenced-by-count":24,"title":["Combination of Immunotherapy and Brain Radiotherapy in Metastatic Melanoma: A Retrospective 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