{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:01:13Z","timestamp":1790420473413,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; In-hospital mortality for patients presenting with acute pulmonary embolism (PE) has been reported to be up to 7 times higher for patients with decreased estimated glomerular filtration rate (eGFR). However, few studies have assessed its effect on long-term mortality. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To determine the impact of eGFR and creatinine clearance (CrCl) on long-term all-cause mortality following acute PE in association with other routine laboratory analyses and comorbidities. &lt;b&gt;&lt;i&gt;Patients\/Methods:&lt;\/i&gt;&lt;\/b&gt; The prospective study enrolled 141 consecutive patients presenting with objectively confirmed acute PE. Demographic, clinical data, comorbidities, and laboratory values were recorded. CrCl and GFR were estimated using the Cockcroft-Gault, MDRD, and chronic kidney disease (CKD)-EPI equations. Patients were followed up at 90 days and 1 year after the event. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In univariate analyses, age, active cancer, PE severity index (PESI), CrCl and eGFR, D-dimer value, and high-density lipoprotein level were found to be significantly associated with mortality in 90 days and 1 year. Additionally, body mass index was significant in the 1-year follow-up. CrCl by Cockcroft-Gault (90-day: area under the curve [AUC] 0.763; 1-year: AUC 0.718) demonstrated higher discriminatory power for predicting mortality than eGFR by the MDRD (AUC 0.686; AUC 0.609) and CKD-EPI (AUC 0.697; AUC 0.630) equations. In multivariate analyses, active cancer, CrCl by Cockcroft-Gault (90-day: hazard ratio [HR] 0.948, 95% CI 0.919\u20130.979; 1-year: HR 0.967, 95% CI 0.943\u20130.991), eGFR by CKD-EPI (90-day: HR 0.948, 95% CI 0.915\u20130.983; 1-year: HR 0.971, 95% CI 0.945\u20130.998) were found to be independent predictors of mortality. eGFR by MDRD, D-dimer, and PESI value were significant prognostic factors for 90-day mortality. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Decreased renal function is a prognostic factor for increased all-cause mortality 90 days and 1 year after acute PE.<\/jats:p>","DOI":"10.1159\/000497436","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T22:01:24Z","timestamp":1549317684000},"page":"264-272","source":"Crossref","is-referenced-by-count":21,"title":["Glomerular Filtration Rate as a Prognostic Factor for Long-Term Mortality after Acute Pulmonary Embolism"],"prefix":"10.1159","volume":"28","author":[{"given":"Valdis","family":"\u0122\u012bbietis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Kigitovi\u010da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"V\u012btola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sintija","family":"Strautmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andris","family":"Skride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.02.035"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2007.10.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1311-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.580506"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.716951"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.4.978"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.08.042"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007030308"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.113944"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-012-0892-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.04.028"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00250112"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03762.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0649-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.5.445"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301884"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200907-1141OC"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.937441"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.10.011"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5152\/akd.2014.5739"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.07.003"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-014-1101-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12420"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.03.009"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.07.107"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000028422.51668.A2"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:18:17Z","timestamp":1745425097000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,6,12]]},"published-print":{"date-parts":[[2019,6,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000497436","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}