{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:30:03Z","timestamp":1771299003759,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; The importance of adjuvant radiotherapy in patients with close margin resections for mucoepidermoid carcinoma of the parotid gland remains unclear. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients who underwent parotidectomy for mucoepidermoid carcinoma with or without adjuvant radiotherapy at a single academic tertiary care center from 2000 to 2014 were identified. Included patients had negative but close (\u22642 mm) surgical margins without other high-risk histopathological factors including advanced T-stage, positive nodal disease, lymphovascular or perineural invasion, or high-grade histology. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt;&lt;i&gt;&lt;\/i&gt; Nineteen patients were identified, of whom 15 (79%) were observed postoperatively, while 4 (21%) underwent adjuvant radiotherapy. There were no significant differences in extent of parotidectomy, elective neck dissection, T staging, or tumor size between patients who were observed and those undergoing adjuvant radiation. There were no locoregional or distant recurrences in any patients at a mean follow up 74.3 months. Patients undergoing adjuvant radiation, however, had significantly more intermediate-grade as compared to low-grade histology (75% vs. 13%, difference 62%, 95% CI 4% to 100%). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Patients with negative but close (\u22642 mm) surgical margins without other high-risk histopathological factors have excellent long-term locoregional control with surgery alone. The effects of adjuvant radiotherapy for those who have intermediate-grade disease remain uncertain.<\/jats:p>","DOI":"10.1159\/000497438","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T21:01:16Z","timestamp":1554238876000},"page":"55-62","source":"Crossref","is-referenced-by-count":23,"title":["Mucoepidermoid Carcinoma of the Parotid: Very Close Margins and Adjuvant Radiotherapy"],"prefix":"10.1159","volume":"81","author":[{"given":"Joseph","family":"Zenga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zizi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuraag","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny\u00a0X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derrick\u00a0T.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin\u00a0S.","family":"Emerick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William\u00a0C.","family":"Faquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark\u00a0A.","family":"Varvares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel\u00a0G.","family":"Deschler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813489659"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815a6b0b"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/his.12488"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3053-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24238"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870030054008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5353-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00464-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/345128"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21477"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21843"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0788"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.10.043"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000321"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-125"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.090"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00484-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(99)80677-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817751072"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23825"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23256"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.01.008"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:18:18Z","timestamp":1745425098000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,4,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000497438","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}