{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:35:10Z","timestamp":1761824110814,"version":"3.40.5"},"reference-count":43,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Neurosurg"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Large population-based studies are needed to assess the epidemiology and survival risk factors associated with pediatric brainstem gliomas. This retrospective study explores factors that may influence survival in this population. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Utilizing the SEER database, the authors retrospectively assessed survival in histologically confirmed brainstem gliomas in patients aged 17 and younger. Survival was described with Kaplan-Meyer curves and multivariate regression analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; This analysis of 180 cases showed that age (hazard ratio [HR] 1.04, 95% CI 0.96\u20131.14, &lt;i&gt;p&lt;\/i&gt; = 0.34), non-white race (HR 1.00, 95% CI 0.35\u20132.85 &lt;i&gt;p&lt;\/i&gt; &amp;#x3e; 0.99), distant or invasive extension of the tumor (HR 0.4, 95% CI 0.08\u20132.53, &lt;i&gt;p&lt;\/i&gt; = 0.37), and radiation therapy (HR 1.27, 95% CI 0.52\u20133.11, &lt;i&gt;p&lt;\/i&gt; = 0.61) were not associated with decreased survival. High-grade tumor status (HR 8.64, 95% CI 3.49\u201321.41, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) was associated with decreased survival. Partial resection (HR 0.11, 95% CI 0.04\u20130.30, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) and gross-total resection (HR 0.03, 95% CI 0.01\u20130.14, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) were associated with improved survival. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; High-grade brainstem gliomas have a worse prognosis. Early diagnosis and surgery appear to be associated with improved survival, while the role of radiation is unclear.<\/jats:p>","DOI":"10.1159\/000497440","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T21:00:50Z","timestamp":1554411650000},"page":"151-164","source":"Crossref","is-referenced-by-count":10,"title":["Pediatric Brainstem Gliomas: A Retrospective Study of 180 Patients from the SEER 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