{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:23:26Z","timestamp":1785306206694,"version":"3.55.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Purpose:<\/i><\/b> The current body of evidence on the efficacy and safety of anti-VEGFs for macular oedema secondary to branch retinal vein occlusion (BRVO) is steadily growing as large clinical trials and observational studies are continually completed. The aim of this meta-analysis is to analyse anatomical and functional outcomes in response to anti-VEGF therapy using evidence generated from a pooled analysis of current clinical trials and observational studies. <b><i>Methods:<\/i><\/b> The current meta-analysis includes treatment of BRVO with aflibercept, bevacizumab and ranibizumab from randomised controlled trials and observational studies. Inclusion criteria included peer-reviewed publications with at least a 12-month follow-up period. On literature review using multiple electronic databases (PubMed, Embase and Cochrane), 22 studies met the inclusion criteria. Baseline patient characteristics, study design, sample size and 12- and 24-month change in best corrected visual acuity (BCVA) and central foveal thickness (CFT) as measured on optical coherence tomography imaging were pooled in a meta-analysis. Data were then stratified by study design and anti-VEGF therapy in subgroup analyses. <b><i>Results:<\/i><\/b> A total of 1,236 eyes from 22 studies were included in this meta-analysis. Mean baseline BCVA ranged from 66 ETDRS letters (20\/50 Snellen equivalent) to 35 letters (20\/200 Snellen). Mean baseline CFT ranged from 406.0 to 681.0 \u00b5m. Anti-VEGF treatment demonstrated an overall mean improvement in BCVA at 12 months of 14 letters (95% CI 12.0 to 16.2, <i>p<\/i> &#x3c; 0.001) and CFT reduction of 228 \u00b5m (95% CI \u2013278.9 to \u2013176.1, <i>p<\/i> &#x3c; 0.001). The BCVA gains at 12 months were maintained to month 24 with a mean gain of 12.5 letters (95% CI 6.3 to 18.8, <i>p<\/i> &#x3c; 0.001), as well as reduction of CFT of 238 \u00b5m (95% CI \u2013336.0 to \u2013140.2, <i>p<\/i> &#x3c; 0.001). No cases of endophthalmitis or glaucoma were reported in any study. <b><i>Conclusion:<\/i><\/b> This meta-analysis confirms the comparable safety and efficacy of anti-VEGF therapies for patients with cystoid macular oedema secondary to BRVO. There is a need for randomised prospective comparative trials of anti-VEGF agents for BRVO.<\/jats:p>","DOI":"10.1159\/000497492","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T21:00:35Z","timestamp":1559595635000},"page":"163-177","source":"Crossref","is-referenced-by-count":13,"title":["Current Outcomes of Anti-VEGF Therapy in the Treatment of Macular Oedema Secondary to Branch Retinal Vein Occlusions: A Meta-Analysis"],"prefix":"10.1159","volume":"242","author":[{"given":"Kimberly","family":"Spooner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Fraser-Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew\u00a0A.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.07.017"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.058"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-010-0025-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301859"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008158"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.04.006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S7631"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/95103"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/tjo.tjo_9_17"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.12.037"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.10"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.09.035"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0798-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8421940"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/1120672117750058"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000111"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001579"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20170601-04"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12772"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S107594"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199552"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.08.013"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S137380"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S58468"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001070"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303121"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0538-y"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306236"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3130-z"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-015-0066-6"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-014-0002-1"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20140404-01"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.874488"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13396"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:18:59Z","timestamp":1745425139000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,9,27]]},"published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000497492","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}