{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:43:38Z","timestamp":1760985818543,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Objective:<\/i><\/b> To investigate the association between the cytokeratin (CK)-1 single-nucleotide polymorphism (SNP), the protein level of CK-1 and the risk of vocal leukoplakia and laryngeal squamous cell carcinoma (LSCC). <b><i>Methods:<\/i><\/b> In this case-control study, 155 patients with vocal leukoplakia, 323 patients with LSCC, and 266 healthy controls were genotyped for the CK-1 (SNP RS14024) gene using pyrosequencing. The protein expression level of CK-1 was analyzed in vocal leukoplakia, LSCC, and vocal polyp patients by immunohistochemistry (IHC). <b><i>Results:<\/i><\/b> Of the CK-1 RS14024 polymorphism, the heterozygote AG and homozygote GG genotype exhibited a significantly increased risk of LSCC (AG: OR = 2.16, <i>p<\/i> = 0.014; GG: OR = 2.15, <i>p<\/i> = 0.018) compared to normal controls. A higher protein expression level of CK-1 was detected in patients with LSCC compared to vocal leukoplakia and polyps (both <i>p<\/i> &#x3c; 0.001), and a significant increasing trend of CK-1 protein expression level from mild-moderate dysplasia to moderate-severe dysplasia in vocal leukoplakia patients was also observed (<i>p<\/i> = 0.006). <b><i>Conclusions:<\/i><\/b> This study demonstrates that the CK-1 SNP and high protein expression levels are associated with vocal leukoplakia and LSCC and promote the transformation from vocal leukoplakia to LSCC in a Chinese Han population.<\/jats:p>","DOI":"10.1159\/000497747","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T21:01:02Z","timestamp":1557349262000},"page":"121-129","source":"Crossref","is-referenced-by-count":5,"title":["Significance of Cytokeratin-1 Single-Nucleotide Polymorphism and Protein Level in Susceptibility to Vocal Leukoplakia and Laryngeal Squamous Cell Carcinoma"],"prefix":"10.1159","volume":"81","author":[{"given":"Yue","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1586\/14737140.2013.829643"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1111\/j.1600-0714.1985.tb00549.x"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1186\/1471-2407-12-47"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1007\/s12032-010-9763-1"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1159\/000163030"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1159\/000103872"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1371\/journal.pone.0171116"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1097\/MD.0000000000007033"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1002\/lary.22417"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1007\/s00418-008-0435-6"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1111\/j.1469-7580.2009.01066.x"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1002\/bies.10140"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1016\/S0955-0674(01)00301-5"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1038\/sj.cdd.4400988"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1016\/j.yexcr.2007.04.023"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1111\/j.1600-0625.2008.00775.x"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1182\/blood.V97.8.2342"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1073\/pnas.95.7.3615"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1016\/j.bbamcr.2015.09.002"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1371\/journal.pone.0000697"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1242\/jcs.116574"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1056\/NEJMra040319"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1371\/journal.pone.0186409"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1016\/S1368-8375(00)00094-4"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.3892\/or.18.3.639"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1097\/PAP.0000000000000106"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1016\/S1368-8375(03)00078-2"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:21:54Z","timestamp":1745425314000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":27,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2019,7,24]]},"published-print":{"date-parts":[[2019,7,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000497747","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2019]]}}}