{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T10:55:06Z","timestamp":1764413706686,"version":"3.40.5"},"reference-count":39,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Objectives:<\/i><\/b> We investigated the clinical, electrocardiographic, and echocardiographic determinants of the cardiac status in nonagenarian patients. <b><i>Methods:<\/i><\/b> We consecutively examined 654 Caucasian patients (232 males and 422 females) aged \u226590 years. All patients underwent clinical examination, ECG, and transthoracic echocardiography. <b><i>Results:<\/i><\/b> Their average age was 92.5 \u00b1 2.5 years. Patients were predominately female of older age (<i>p<\/i> &#x3c; 0.0001 and <i>p<\/i> = 0.02, respectively). A history of cardiovascular disease was present in 78.4% of the participants. One third of the patients was hospitalized for cardiovascular causes, with females being twice as many (<i>p<\/i> &#x3c; 0.0001). Females showed higher levels of serum cholesterol, triglycerides, and glycemia (<i>p<\/i> &#x3c; 0.0001, <i>p<\/i>&#x3c; 0.0001, and <i>p<\/i> = 0.04 respectively). Sinus rhythm was detected in 65%, and atrial fibrillation in 31% of the overall population. Heart rate, PR and corrected QT (QTc) intervals, right bundle branch block (RBBB) and RBBB associated with left anterior fascicular block (LAFB) were higher in males (<i>p<\/i> &#x3c; 0.0001, <i>p<\/i> = 0.036, <i>p<\/i> = 0.009, <i>p<\/i> = 0.001, and <i>p<\/i> = 0.004, respectively). Aortic root dimension, left ventricular (LV) mass index, and indexed LV systolic-diastolic volumes were higher in males (<i>p<\/i> &#x3c; 0.001, <i>p<\/i> &#x3c; 0.0001, <i>p<\/i> &#x3c; 0.001, and <i>p<\/i> &#x3c; 0.0001, respectively). Women showed fewer LV segmental kinetic disorders (<i>p<\/i> = 0009) and higher LV ejection fraction (LVEF; <i>p<\/i>&#x3c; 0.0001). Hyperuricemia was positively associated with a history of cardiovascular disease (<i>r<\/i> = 0.15), glycemia (<i>r<\/i> = 19), creatininemia (<i>r<\/i> = 0.50), uremia (<i>r<\/i> = 0.51), triglycerides (<i>r<\/i> = 0.19), PR interval (<i>r<\/i> = 0.14), and left bundle branch block (<i>r<\/i> = 0.11), and inversely associated with sinus rhythm (r = \u20130.14) and LVEF (<i>r<\/i> = \u20130.17). Diabetes was positively correlated with PR and QTc intervals (<i>r<\/i> = 0.14 and <i>r<\/i> = 0.10, respectively), and RBBB with LFAB (<i>r<\/i> = 0.10), and inversely correlated with LVEF (<i>r<\/i> = \u20130.10). <b><i>Conclusions:<\/i><\/b> We found a remarkable presence of cardiovascular risk factors, ECG, and structural alterations in hospitalized nonagenarians, which presents more commonly in males.<\/jats:p>","DOI":"10.1159\/000497812","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T21:01:17Z","timestamp":1558472477000},"page":"485-494","source":"Crossref","is-referenced-by-count":3,"title":["Clinical, Electrocardiographic, and Echocardiographic Features in Hospitalized Nonagenarians (90+): Comparison between the Genders"],"prefix":"10.1159","volume":"65","author":[{"given":"Dimitri","family":"Tsialtas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u00a0Giulia","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephania","family":"Assimopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Aldigeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-5949","authenticated-orcid":false,"given":"Roberto","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2009.07.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.06.051"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61347-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01180.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.05.016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a000810"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076813"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145615.33955.83"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2005.00940.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.19.2343"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0626-x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.03.017"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-017-0255-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.10.035"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a061848"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-12-15"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.6.585"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl259"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.22.2494"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.06.055"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.6.625"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.07.046"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.637389"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-016-0667-6"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001107"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000549"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2011.08.011"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.937821"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.218271"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.08.678"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.08.001"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7184123"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.5414\/CN109401"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-014-0077-9"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02707-y"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02630.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0687"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:22:30Z","timestamp":1745425350000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,8,21]]},"publishe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