{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:26:10Z","timestamp":1774502770884,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Nail changes are a common side effect of taxane chemotherapy, although their correct management is poorly standardized. <b><i>Objective:<\/i><\/b> To evaluate incidence, clinical aspects, and response to treatment of taxane-induced nail side effects in patients treated with taxanes for malignancies. <b><i>Patients and Methods:<\/i><\/b> We performed a retrospective clinical study of 79 patients with taxane-induced nail changes from January 2015 to July 2018. <b><i>Results:<\/i><\/b> Paclitaxel was the most responsible drug and both hands and feet were often affected (46.8%). Grade 2 nail toxicity was seen in 63.3% of the patients, including painful subungual hematoma, hemorrhagic onycholysis, and paronychia. Grade 3 nail toxicity was seen only in 2.5% of the patients, including hemorrhagic onycholysis and pyogenic granuloma. Removal of the detached nail plate with application of topical antibiotics and steroids induced regression of symptoms within 2 weeks. <b><i>Conclusions:<\/i><\/b> Nail toxicity develops mostly at the end of therapy, and total drug dosage is the only known factor that predisposes to these side effects. Trauma possibly plays a role as the most severe signs are located on the great toenails. Although it is impossible to prevent taxane-induced nail side effects, a careful patient monitoring permits to immediately recognize and manage the symptoms in order to induce their remission and improvement of the patient\u2019s quality of life.<\/jats:p>","DOI":"10.1159\/000497824","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T22:00:30Z","timestamp":1553292030000},"page":"276-282","source":"Crossref","is-referenced-by-count":19,"title":["Management and Outcome of Taxane-Induced Nail Side Effects: Experience of 79 Patients from a Single Centre"],"prefix":"10.1159","volume":"5","author":[{"given":"Aurora","family":"Alessandrini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Starace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Cer\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-3455","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca\u00a0Maria","family":"Piraccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg050"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.06.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71133-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199704000-00006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00774.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03692.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18307"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04210-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000486021"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23333"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.15.651"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.3465"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/497824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:22:35Z","timestamp":1745425355000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000497824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,8,14]]},"published-print":{"date-parts":[[2019,8,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000497824","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}