{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:01:52Z","timestamp":1781103712921,"version":"3.54.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The treatment of relapsed\/refractory (R\/R) peripheral T cell lymphoma (PTCL) is limited to a few agents. Romidepsin, a histone deacetylase inhibitor, was approved for PTCL treatment as a single agent in the R\/R setting, yet with partial efficacy. Several attempts to combine romidepsin with other chemotherapy regimens have been reported, however, with significant toxicity. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To study the romidepsin-bendamustine combination in PTCL in an attempt to maximize efficacy while minimizing toxicity. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We report on a series of 7 heavily pretreated PTCL patients (2\u20135 previous lines of therapy) treated with a romidepsin-bendamustine combination. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Four patients were not previously exposed to either drug. Of these, 2 achieved complete remission. Interestingly, 1 patient continued treatment with a prolonged progression-free survival of more than 4 years. Toxicity was minimal and no treatment-related deaths or discontinuation were noted. Significant nausea and vomiting were reported in over 50% of patients. Hematological toxicity was mild and lower than that reported for other romidepsin-chemotherapy combinations and was correlated with bone marrow involvement by lymphoma. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Although reporting a small number of patients, our data suggest that the combination of romidepsin and bendamustine may be a feasible therapeutic option in R\/R PTCL patients and merits further study.<\/jats:p>","DOI":"10.1159\/000498905","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T22:06:20Z","timestamp":1554329180000},"page":"216-221","source":"Crossref","is-referenced-by-count":13,"title":["Romidepsin-Bendamustine Combination for Relapsed\/Refractory T Cell Lymphoma"],"prefix":"10.1159","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-2167","authenticated-orcid":false,"given":"Boaz","family":"Nachmias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adir","family":"Shaulov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lavie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neta","family":"Goldschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revital","family":"Saban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-4482","authenticated-orcid":false,"given":"Moshe\u00a0E.","family":"Gatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-692566"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-312603"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2174\/138920007780655397"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13062"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.4223"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2320"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.83"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00023-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10764"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.7285"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2011.03.003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1063143"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806737"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/498905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/498905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:23:12Z","timestamp":1745425392000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000498905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,5,15]]},"published-print":{"date-parts":[[2019,5,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000498905","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}