{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:37:21Z","timestamp":1768401441634,"version":"3.49.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; To compare the efficacy of aflibercept (Eylea\u00ae), a potent antivascular endothelial growth factor (VEGF) agent, with betamethasone (Celestone\u00ae) and placebo for the treatment of formed corneal neovascularization in a rabbit model. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A central corneal chemical burn was created in the right eye of 24 New Zealand albino rabbits. Four weeks later, the rabbits were randomly divided into 4 equal groups for subconjunctival injection of aflibercept, betamethasone, aflibercept+ betamethasone, or saline (control). Digital photographs taken at weekly intervals were rated by 2 masked observers for extent, centricity, and density of corneal neovascularization according to a predefined scale. The percentage of corneal surface involved by neovascularization was quantified by image analysis software (Fiji-J). The change in corneal neovascularization from treatment administration (4 weeks after injury) to 4 weeks later (8 weeks after injury) was assessed. The rabbits were then euthanized, and their eyes were enucleated and processed for histopathological and immunofluorescence studies. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; There was no significant difference in the change in corneal neovascularization after treatment among the 4 groups according to the digital images (&lt;i&gt;p&lt;\/i&gt; &amp;#x3e; 0.15) or histological evaluation with hematoxylin and eosin (&lt;i&gt;p&lt;\/i&gt; &amp;#x3e; 0.08). On immunofluorescence assay, a lower VEGF concentration was observed in all treatment groups compared to the control group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In this rabbit model, corneal neovascularization induced by chemical burn failed to regress with treatment with aflibercept, betamethasone, or their combination.<\/jats:p>","DOI":"10.1159\/000499165","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T21:01:17Z","timestamp":1558472477000},"page":"116-122","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of Subconjunctival Aflibercept and Betamethasone for the Treatment of Formed Corneal Neovascularization in a Rabbit Model"],"prefix":"10.1159","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-0906","authenticated-orcid":false,"given":"Maya","family":"Eiger-Moscovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitan","family":"Livny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-4685","authenticated-orcid":false,"given":"Ruti","family":"Sella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orly","family":"Gal-Or","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Nisgav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Livnat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Bahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2016.03.021"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000849"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2011.204701"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.039"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/178132"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000507"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094205"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1997"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.107912"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01571.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/02713680903429007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.03.010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4571"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2013.850098"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000224783"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181b1c82f"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318159019f"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318221ce99"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0036-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02252.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2014.10.002"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:26:23Z","timestamp":1745425583000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,7,24]]},"published-print":{"date-parts":[[2019,7,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000499165","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}