{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:06Z","timestamp":1745426406576,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To assess interruptions\/discontinuations of tyrosine kinase inhibitor (TKI) treatment in Belgian patients with chronic myeloid leukaemia (CML). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This retrospective study included patients with TKI interruptions\/discontinuations of \u22654 continuous weeks (no clinical trial context) between May 2013 and May 2016. Data collection took place between October 2016 and February 2017. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All 60 participants (69 interruptions\/discontinuations) had chronic-phase CML and 75% had at least a major molecular response (\u2265MMR) at interruption\/discontinuation. Most interruptions\/discontinuations occurred while on imatinib (36\/69; 49%) and dasatinib (20\/69; 29%). Most interruptions\/discontinuations occurred due to side effects\/intolerance (46\/69; 67%); other reasons included a wish to conceive (6\/69; 9%) and attempts to achieve treatment-free remission (TFR) (6\/69; 9%). Interruptions due to side effects occurred later for imatinib- or dasatinib-treated patients than for those on nilotinib or ponatinib. Treatment was re-initiated in 62% (43\/69) of cases. Most interruptions caused by side effects\/intolerance were followed by treatment changes. All 4 patients with \u2265MR 4.5 at interruption\/discontinuation and \u226511-month follow-up who had not restarted treatment maintained the response. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Although TKIs are used for long-term CML treatment, physicians sometimes recommend interruptions\/discontinuations. In this study, interruptions\/discontinuations were mainly caused by side effects or intolerance, rather than TFR attempts.<\/jats:p>","DOI":"10.1159\/000499329","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T21:00:34Z","timestamp":1559682034000},"page":"197-207","source":"Crossref","is-referenced-by-count":6,"title":["Interruption or Discontinuation of Tyrosine Kinase Inhibitor Treatment in Chronic Myeloid Leukaemia: A Retrospective Cohort Study (SPARKLE) in 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