{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:19:34Z","timestamp":1789395574494,"version":"build-2803163510"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to evaluate whether a new MRI scoring system for preterm non-haemorrhagic white matter injury (WMI), derived from the analysis of the natural evolution of WMI throughout the neonatal period until term-equivalent age, can be used for outcome prediction. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Eighty-two infants &amp;#x3c;36 weeks gestation with WMI diagnosed from sequential cranial ultrasound and confirmed on neonatal MRI were retrospectively included. WMI was classified in four grades of severity. Neurodevelopmental data at a median age of 24 months were analysed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In 74 surviving children WMI severity was strongly associated with the presence and severity of cerebral palsy (CP) and other neurodevelopmental impairments (Spearman\u2019s rank correlation 0.88, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). Only 3 children with grade I WMI (9%) developed CP (all ambulant) and their developmental scores were not different to those from the controls, although they started walking significantly later (&lt;i&gt;p&lt;\/i&gt; = 0.036). Of the 6 children with grade II, 83% developed CP (mild in most), whereas 91% of the 34 children with grade III had CP (moderate-severe in 76%) and all had some degree of neurodevelopmental impairment. Three children with grade III WMI did not develop CP; their imaging showed, in contrast to children who developed CP, that the cysts did not affect the corticospinal tracts; also, myelin in the posterior limb of the internal capsule appeared normal in 2 children and suboptimal in 1. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This MRI scoring system for preterm WMI can be used to predict neurodevelopmental outcomes. Individualized assessment of the site of lesions and the progression of myelination improves prognostic accuracy.<\/jats:p>","DOI":"10.1159\/000499346","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T21:00:36Z","timestamp":1558386036000},"page":"227-235","source":"Crossref","is-referenced-by-count":47,"title":["Neurodevelopmental Outcomes in Preterm Infants with White Matter Injury Using a New MRI Classification"],"prefix":"10.1159","volume":"116","author":[{"given":"Miriam","family":"Martinez-Biarge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-1637","authenticated-orcid":false,"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina\u00a0J.","family":"Kersbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon\u00a0J.N.L.","family":"Benders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Foti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid\u00a0C.","family":"van\u00a0Haastert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances\u00a0M.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda\u00a0S.","family":"de\u00a0Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.12.053"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12865"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.034"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2247"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12972"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80189-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003606"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053792"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3521"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.12.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156245"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13753-x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-1691"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110797"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108904"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.3.F171"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.3.F151"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1545666"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2016.09.009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313102"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051879"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313572"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.05.013"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.70"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:12Z","timestamp":1745425632000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,10,8]]},"published-print":{"date-parts":[[2019,10,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000499346","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}