{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:42Z","timestamp":1791495162231,"version":"4.3.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; In order to increase overall participation in cervical cancer screening, several investigators propose a concept of introducing self-tests. The study presented here compared test results of the Pap test and 4 different HPV test systems of self-collected and physician-collected vaginal specimens. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; 208 patients of a colposcopy clinic had physician-taken and self-taken vaginal samples. All cell samples enabled a liquid-based Pap test and testing for carcinogenic HPV genotypes. In addition, all patients had a colposcopy with or without cervical biopsy and\/or conisation. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 99 patients had the histological diagnosis of CIN2+. The HPV test sensitivity of self-collected samples differed significantly in this patient group depending on the test system performed. The sensitivity of the self-collected Pap test was significantly lower than HPV testing, but the positive predictive value of the Pap self-test was very high. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The results of this study indicate that under the circumstances of self-testing HPV test systems differ in test sensitivity and specificity. Self-collected Pap tests can provide a test result with a very high positive predictive value and introduce therapeutic strategies. In order to improve screening strategies, it could be an opportunity to combine HPV and Pap tests in self-taken vaginal samples, especially in countries with a low income level. In countries with a good medical infrastructure, self-testing has to be introduced with caution.<\/jats:p>","DOI":"10.1159\/000499373","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T21:02:19Z","timestamp":1556571739000},"page":"379-384","source":"Crossref","is-referenced-by-count":18,"title":["Self-Collected Samples in Cervical Cancer Screening: Results of HPV and Pap Self-Collected Samples Compared to Physician-Obtained Specimens"],"prefix":"10.1159","volume":"63","author":[{"given":"Bernhard\u00a0Reinhold","family":"Mangold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3812"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2018.12.021"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000331811"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30579"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2011.03.018"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr544"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr532"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0307"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.1.81"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.01.023"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1040"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.zefq.2014.08.001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-135"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.3.1330-1332.2004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-243"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1370\/afm.90"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000477331"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25144"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:22Z","timestamp":1745425642000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,8,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000499373","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}