{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:22:26Z","timestamp":1792678946567,"version":"4.5.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Background: Tachycardia worsens cardiac performance in acute decompensated heart failure (ADHF). We investigated whether heart rate (HR) optimization by landiolol, an ultra-short-acting \u03b21-selective blocker, in combination with milrinone improved cardiac function in patients with ADHF and rapid atrial fibrillation (AF). Methods and Results: We enrolled9 ADHF patients (New York Heart Association classification IV; HR, 138 \u00b1 18 bpm; left ventricular [LV] ejection fraction, 28 \u00b1 8%; cardiac index [CI], 2.1 \u00b1 0.3 L\/min\u20131\/m\u20132; pulmonary capillary wedge pressure [PCWP], 24 \u00b1 3 mm Hg), whose HRs could not be reduced using standard treatments, including diuretics, vasodilators, and milrinone. Landiolol (1.5\u20136.0 \u00b5g\/kg\u20131\/min\u20131, intravenous) was added to milrinone treatment to study its effect on hemodynamics. The addition of landiolol (1.5 \u00b5g\/kg\u20131\/min\u20131) significantly reduced HR by 11% without changing systolic blood pressure (BP) and resulted in a significant decrease in PCWP and a significant increase in stroke volume index (SVI), suggesting that HR reduction restores incomplete LV relaxation. Administration of more than 3.0 \u00b5g\/kg\u20131\/min\u20131 of landiolol decreased BP, CI, and SVI. Conclusion: The addition of landiolol at doses of &lt;3.0 \u00b5g\/kg\/min to milrinone improved cardiac function in decompensated chronic heart failure with rapid atrial fibrillation by selectively reducing HR.<\/jats:p>","DOI":"10.1159\/000499400","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T21:00:47Z","timestamp":1559077247000},"page":"195-202","source":"Crossref","is-referenced-by-count":12,"title":["Addition of a \u03b21-Blocker to Milrinone Treatment Improves Cardiac Function in Patients with Acute Heart Failure and Rapid Atrial Fibrillation"],"prefix":"10.1159","volume":"142","author":[{"given":"Shigeki","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeki","family":"Myoren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Kajii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Nanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Ishiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiro","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Uchinoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yoshiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-3768","authenticated-orcid":false,"given":"Reo","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.10.1375"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00854-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/hc1102.105270"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114314"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.038"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-008-0640-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-0033"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000355312"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.069"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.5.1743"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.05.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-1618"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/crd\/article-pdf\/142\/4\/195\/3897101\/000499400.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/142\/4\/195\/3897101\/000499400.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:28Z","timestamp":1745425648000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,8,8]]},"published-print":{"date-parts":[[2019,8,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000499400","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}