{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:27:36Z","timestamp":1745468856883,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Noncompaction cardiomyopathy (NC) is a rare congenital heart disease characterized by progressive heart failure and life-threatening arrhythmias. Heart rate turbulence (HRT) has been defined as a noninvasive prognostic method to reveal the cardiac death risk in high-risk patients. <b><i>Objectives:<\/i><\/b> We aimed to assess the cardiac autonomic functions and their relations to the mortality in NC patients. <b><i>Methods:<\/i><\/b> A total of 60 NC patients and 70 healthy controls were included in this study. All participants underwent 24-h Holter recording to assess the HRT parameters, included turbulence onset (TO), turbulence slope (TS), standard deviation of NN intervals of all normal beats (SDNN) and mean RR interval. <b><i>Results:<\/i><\/b> NC patients had higher levels of TO than the control group (0.43 \u00b1 4.66% vs. \u20131.82 \u00b1 2.19%, <i>p<\/i> = 0.024), but the TS levels of NC patients were lower than those of the control group (3.43 \u00b1 3.28 vs. 4.94 \u00b1 2.86 ms\/RR, <i>p<\/i> = 0.024). Thirteen patients died during follow-up (mean 83.3 \u00b1 32.5 months). TS was the strongest univariate mortality predictor (hazard ratio 10.01 [95% CI 2.22\u201342.52]; <i>p<\/i> = 0.004) in univariate Cox regression analysis. In multivariate analysis, LVEF \u22640.40 and TS \u22642.5 ms\/RR interval were the only independent predictors of mortality (hazard ratio 5.29; <i>p<\/i> = 0.004, hazard ratio 13.45; <i>p<\/i> = 0.001, respectively). <b><i>Conclusions:<\/i><\/b> Patients with NC showed abnormal HRV and HRT parameters when compared to healthy subjects. Furthermore, impaired HRT reaction in NC is an independent predictor of mortality.<\/jats:p>","DOI":"10.1159\/000499408","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T21:00:34Z","timestamp":1555102834000},"page":"56-62","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Significance of Heart Rate Turbulence Parameters in Patients with Noncompaction Cardiomyopathy"],"prefix":"10.1159","volume":"142","author":[{"given":"Baris","family":"Bugan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif\u00a0Ijlal","family":"Cekirdekci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.6.666"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02325.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800040-3.00008-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000064677"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016333109829"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000445881"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08428-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu176"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp595"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.041"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308113090602"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11144-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.5.1471"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.22543\/7674.42.P115124"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02198-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90970-N"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1542-474X.2003.08406.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi188"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000088783.34082.89"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.08.049"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318225768b"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:34Z","timestamp":1745425654000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,4,30]]},"published-print":{"date-parts":[[2019,5,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000499408","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2019]]}}}