{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:17:47Z","timestamp":1784081867908,"version":"3.55.0"},"reference-count":63,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; This study was aimed at determining the intraocular pharmacokinetics based on molecular physicochemical properties in a rabbit model. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The entire dataset was obtained from previous literature, and research articles regarding 70 molecular compounds were investigated. The intravitreal half-lives in rabbit eyeballs of 22 macromolecules and 48 micromolecules were analyzed. Multiple linear regression analysis was carried out with non-collinear independent variables (molecular weight [MW] and lipophilicity) influencing intravitreal half-lives. The best-fit equations were selected based on the correlation coefficients and goodness-of-fit statistics. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The best-fit models obtained from the entire dataset, macromolecules, and micromolecules suggest the correlation between molecular physicochemical properties (MW and lipophilicity) and intravitreal half-life. Exclusion of outlier molecules (amphotericin B and foscarnet) leads to a better-fit correlation. MW is the definite single factor affecting intravitreal half-lives of macromolecules (Log &lt;i&gt;t&lt;\/i&gt;&lt;sub&gt;1\/2&lt;\/sub&gt; = 0.148 + 0.370 Log MW, &lt;i&gt;R&lt;\/i&gt;&lt;sup&gt;2&lt;\/sup&gt; = 0.769), while both MW and lipophilicity influence the intraocular pharmacokinetics of micromolecules (Log &lt;i&gt;t&lt;\/i&gt;&lt;sub&gt;1\/2&lt;\/sub&gt; = \u20131.213 + 0.762 Log MW \u2013 0.115 Log &lt;i&gt;p&lt;\/i&gt;, &lt;i&gt;R&lt;\/i&gt;&lt;sup&gt;2&lt;\/sup&gt; = 0.554). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The present study indicates that intravitreal half-life could be predicted based on molecular physicochemical properties (MW and lipophilicity). Also, increasing MW while reducing lipophilicity would be a reliable method for prolonging the intravitreal half-life of small chemical drugs, while MW is the single major determinant for large biologic drugs.<\/jats:p>","DOI":"10.1159\/000499529","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T21:01:17Z","timestamp":1558472477000},"page":"41-49","source":"Crossref","is-referenced-by-count":18,"title":["A Prediction Model for the Intraocular Pharmacokinetics of Intravitreally Injected Drugs Based on Molecular Physicochemical 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