{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:30:33Z","timestamp":1787697033947,"version":"build-2784847793"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Fertility and gonadal function represent one of the most important aspects for long-term lymphoma survivors. &lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; The aim of our study was to determine possible risk factors, such as age at treatment, chemotherapeutic regimen, protection with oral contraceptives (OCs), and gonadotropin-releasing hormone (GnRH) analogues in female patients treated for Hodgkin\u2019s lymphoma (HL) or non-Hodgkin lymphoma (NHL) at a reproductive age. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Patients between the age of 16 and 50 years at the time of HL or NHL diagnosis were selected. Eligible patients were requested to respond to a questionnaire by phone interview about fertility, menstrual status, sexual aspects, and treatment with OCs or GnRH analogues during chemotherapy. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The resumption of menstrual activity was associated with the use of the OCs and GnRH analogues during chemotherapy (&lt;i&gt;p&lt;\/i&gt; = 0.008 and 0.034, respectively). At univariate analysis, the use of OCs during chemotherapy was associated with a lower risk of amenorrhea (prevalence ratio [PR] = 0.37; 95% CI 0.17\u20130.82). A higher age at the time of treatment correlated positively with therapy-induced amenorrhea, with a difference of 12.8 years between the mean age at diagnosis of the women with therapy-induced amenorrhea and those who resumed their menses. Amenorrhea was significantly higher in women receiving R-CHOP than in women treated with ABVD (PR = 6.00; 95% CI 2.32\u201315.54). Moreover, NHL had an infertility PR of 1.51 (95% CI 0.86\u20132.45) at multivariate analysis compared to HL. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This study suggests a possible role of pharmacological prophylaxis with OCs and GnRH analogues.<\/jats:p>","DOI":"10.1159\/000499535","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T21:01:42Z","timestamp":1558558902000},"page":"36-41","source":"Crossref","is-referenced-by-count":16,"title":["Gonadal Function Recovery and Fertility in Women Treated with Chemo- and\/or Radiotherapy for Hodgkin\u2019s and Non-Hodgkin Lymphoma"],"prefix":"10.1159","volume":"64","author":[{"given":"Guido","family":"Gini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Annibali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Lupasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Bocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Tomarchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Sampaolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Trappolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0Antonietta","family":"Tafuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Cacciagi\u00f9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariavita","family":"Ciccarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Barucca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sarlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vincenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Avvisati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Leoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0035"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.5168"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008018.pub2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.8864"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.138"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0689-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-21"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv227"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-090225"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.08.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr575"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.1989"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603711"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hon.802"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.0910"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500353877"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2005.08.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq066"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3892\/or.10.1.151"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu036"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:28:57Z","timestamp":1745425737000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,7,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000499535","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}