{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:10:05Z","timestamp":1745428205977,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastrointest Tumors"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>We present a female patient, 13 years old, with diagnosis of hepatocellular carcinoma of fibrolamellar type, which was rapidly evolving. The fibrolamellar hepatocellular carcinoma invaded more than 80% of the hepatic parenchyma without surgical possibility or liver transplantation. Measures applied corresponded to chemotherapy of 1 cycle of cisplatin 40 mg\/s\/5 days + vincristine 1.5 mg\/m&lt;sup&gt;2&lt;\/sup&gt;\/day, 5-fluorouracil, doxorubicin, and dexrazoxane. The case presented aggressive evolution of hepatocellular carcinoma, which led to acute liver failure, with hyperammonemia, sepsis, pulmonary focus plus septic shock, grade III-IV encephalopathy, portal hypertension, and ascites with intra-abdominal hypertension. Death occurred due to multiple organ failure, which involved respiratory failure type KDIGO 1 and 2, acute liver failure, severe pneumonia, pericardial effusion, AKIN 2 acute kidney injury, carcinoma, and pulmonary metastasis. This type of ailment is infrequent in children and adolescents, and the first symptoms are crucial to achieve treatment possibilities.<\/jats:p>","DOI":"10.1159\/000499581","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T21:01:27Z","timestamp":1558990887000},"page":"43-50","source":"Crossref","is-referenced-by-count":3,"title":["Hepatocellular Carcinoma of Fibrolamellar Type in an Adolescent: Case Report and Literature Review"],"prefix":"10.1159","volume":"6","author":[{"given":"Javier","family":"Santiago-Reynoso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina\u00a0Senyase","family":"Zamaripa-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan\u00a0Manuel","family":"Dorantes-Loya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo\u00a0J.","family":"Gayt\u00e1n-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelia","family":"Apolinar-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Paz-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Farias-Serratos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Maldonado-Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1059"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S94008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.917"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80296-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/74.6.827"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24847"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MD"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2016_555"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35722"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.917"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005756"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181bccfb4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1047"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4173\/astr"}],"container-title":["Gastrointestinal Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:29:37Z","timestamp":1745425777000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":14,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2019,8,5]]},"published-print":{"date-parts":[[2019,8,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000499581","archive":["Portico"],"relation":{},"ISSN":["2296-3774","2296-3766"],"issn-type":[{"type":"print","value":"2296-3774"},{"type":"electronic","value":"2296-3766"}],"subject":[],"published":{"date-parts":[[2019]]}}}