{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:54:50Z","timestamp":1761562490565,"version":"3.40.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Objective:<\/i><\/b> Older people approaching the end of life are at a high risk for adverse drug reactions. Approaching the end of life should change the therapeutic aims, triggering a reduction in the number of drugs.<b><i><\/i><\/b>The main aim of this study is to describe the preventive and symptomatic drug treatments prescribed to patients discharged with a limited life expectancy from internal medicine and geriatric wards. The secondary aim was to describe the potentially severe drug-drug interactions (DDI). <b><i>Materials and Methods:<\/i><\/b> We analyzed Registry of Polytherapies Societa Italiana di Medicina Interna (REPOSI), a network of internal medicine and geriatric wards, to describe the drug therapy of patients discharged with a limited life expectancy. <b><i>Results:<\/i><\/b> The study sample comprised 55 patients discharged with a limited life expectancy. Patients with at least 1 preventive medication that could be considered for deprescription at the end of life were significantly fewer from admission to discharge (<i>n<\/i> = 30; 54.5% vs. <i>n<\/i> = 21; 38.2%; <i>p<\/i> = 0.02). Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, lipid-lowering drugs, and clonidine were the most frequent potentially avoidable medications prescribed at discharge, followed by xanthine oxidase inhibitors and drugs to prevent fractures. Thirty-seven (67.3%) patients were also exposed to at least 1 potentially severe DDI at discharge. <b><i>Conclusion:<\/i><\/b> Hospital discharge is associated with a small reduction in the use of commonly prescribed preventive medications in patients discharged with a limited life expectancy. Cardiovascular drugs are the most frequent potentially avoidable preventive medications. A consensus framework or shared criteria for potentially inappropriate medication in elderly patients with limited life expectancy could be useful to further improve drug prescription.<\/jats:p>","DOI":"10.1159\/000499692","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T22:00:32Z","timestamp":1553119232000},"page":"501-508","source":"Crossref","is-referenced-by-count":7,"title":["Need for Deprescribing in Hospital Elderly Patients Discharged with a Limited Life Expectancy: The REPOSI Study"],"prefix":"10.1159","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4777-1350","authenticated-orcid":false,"given":"Luca","family":"Pasina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Brignolo\u00a0Ottolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cortesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Tettamanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Marengoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier\u00a0Mannuccio","family":"Mannucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the\u00a0REPOSI\u00a0Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr059"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2165\/11631740-000000000-00000"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1921"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0541-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.6.605"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13153"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61091-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2007.12.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2014-000767"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF03261971"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1179\/174329111X576698"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.624890"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01704.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1752-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.0324"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1482"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14519"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12418"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12386"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:30:37Z","timestamp":1745425837000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,11,28]]},"published-print":{"date-parts":[[2019,12,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000499692","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2019]]}}}