{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:54:41Z","timestamp":1776862481083,"version":"3.51.2"},"reference-count":35,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> The early diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI) in patients with chronic kidney disease (CKD) remains a challenge. <b><i>Methods:<\/i><\/b> The study consecutively enrolled patients who had suffered from chest pain within 3 h whose electrocardiogram had no elevation in the ST segment. CKD was defined as an estimated glomerular filtration rate (eGFR) &#x3c;60 mL\/min\/1.73 m<sup>2<\/sup>, and the diagnostic criteria for NSTEMI were defined according to the recommended guideline. Circulating microRNA-1 was collected and determined by quantitative real-time reverse transcription polymerase chain reaction. <b><i>Results:<\/i><\/b> A total of 456 patients with suspected NSTEMI were included. There were 115 patients in the CKD group, including 67 with NSTEMI, 20 with stable angina, 7 with unstable angina, 18 with heart failure, and 3 with other disorders. Compared with the NSTEMI group, the non-NSTEMI group just had significant differences in microRNA-1 and high-sensitivity cardiac troponin I (hs-cTnI) (both <i>p<\/i> &#x3c; 0.05). The relative expression of microRNA-1 was significantly increased in the NSTEMI group as compared with that in the other disease groups (all <i>p<\/i> &#x3c; 0.05). A receiver operating characteristic (ROC) curve analysis suggested that microRNA-1 and hs-cTnI had advantages in the early diagnosis of NSTEMI with CKD (AUC [area under the ROC curve] 0.879 and 0.812, respectively, both <i>p<\/i> &#x3c; 0.05). Compared with that in the non-CKD group, the accuracy of microRNA-1 was almost as good in the CKD group (84.3 vs. 89.4%, <i>p<\/i> &#x3e; 0.05). However, the diagnostic accuracy of hs-cTnI was significantly decreased (79.1 vs. 91.5%, <i>p<\/i> &#x3c; 0.05), as was its specificity (75.0 vs. 95.5%, <i>p<\/i> &#x3c; 0.05). There was no significant difference in the correlation between microRNA-1 and eGFR (<i>p<\/i> &#x3e; 0.05), but a statistically significantly negative correlation between hs-cTnI and eGFR (<i>p<\/i> &#x3c; 0.05). <b><i>Conclusion:<\/i><\/b> Circulating microRNA-1 is capable of early diagnosis of NSTEMI in patients with CKD suffering from chest pain.<\/jats:p>","DOI":"10.1159\/000499834","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T22:17:31Z","timestamp":1561414651000},"page":"274-283","source":"Crossref","is-referenced-by-count":2,"title":["Initial Concentrations of miR-1 MicroRNA Precursor and High-Sensitivity Troponin in the Diagnosis of Non-ST Myocardial Infarction among Patients with and Those without Chronic Kidney Disease"],"prefix":"10.1159","volume":"9","author":[{"given":"Tong","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.08.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.07.023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq456"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.205617"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014245"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01176-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.16198"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1714\/2464.25804"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000133"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000135969.33773.0B"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X167462"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028901"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp573"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.107821"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq167"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090645"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041365"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq251"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.185266"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201749"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(95)00027-7"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030320"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.06.054"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12183"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.07.011"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.056"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10471011"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000458451"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/428371"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-012-0461-1"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.1366"}],"container-title":["Cardiorenal 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