{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:43:57Z","timestamp":1784389437911,"version":"3.55.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Purpose:<\/i><\/b> The aim of this study was to quantify the value of various clinical, laboratory, and instrumental signs in the diagnosis of myocarditis in comparison with morphological studies of the myocardium. <b><i>Methods:<\/i><\/b> In 100 patients (65\u00a0men, 44.7 \u00b1 12.5 years old) with \u201cidiopathic\u201d arrhythmias (<i>n<\/i> = 20) and dilated cardiomyopathy (DCM; <i>n<\/i> = 80), we performed the following: 71 endomyocardial biopsies (EMB), 13 intraoperative biopsies, 5 studies of explanted hearts, and 11 autopsies with virus investigation (real-time PCR) of the blood and myocardium. Antiheart antibodies (AHA) were also measured as well as cardiac CT (<i>n<\/i> = 45), MRI (<i>n<\/i> = 25), and coronary angiography (<i>n<\/i> = 47). The comparison group included 50 patients (25 men, 53.7 \u00b1 11.7 years old) with noninflammatory heart diseases who underwent open heart surgery. <b><i>Results:<\/i><\/b> Active\/borderline myocarditis was diagnosed in 76.0% of the study group and in 21.6% of patients in the comparison group (<i>p<\/i> &#x3c; 0.001). The myocardial viral genome was observed more frequently in patients in the comparison group than in the study group (65.0 and 40.2%; <i>p<\/i> &#x3c; 0.01). We evaluated the diagnostic value of noninvasive markers of myocarditis. The panel of AHA had the greatest importance in the identification of myocarditis: sensitivity was 81.5%, and the positive and negative predictive values were 75.0 and 60.5%. This defined the diagnostic value of noninvasive markers of myocarditis and established a diagnostic algorithm providing an individual assessment of the likelihood of myocarditis development. <b><i>Conclusion:<\/i><\/b> AHA have the greatest significance in the diagnosis of latent myocarditis in patients with \u201cidiopathic\u201d arrhythmias and DCM. The use of a complex of noninvasive criteria allows the probability of myocarditis to be estimated and the indications for EMB to be determined.<\/jats:p>","DOI":"10.1159\/000499865","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T21:00:34Z","timestamp":1560373234000},"page":"167-174","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic Value of Different Noninvasive Criteria of Latent Myocarditis in Comparison with Myocardial Biopsy"],"prefix":"10.1159","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-793X","authenticated-orcid":false,"given":"Olga","family":"Blagova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Osipova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nedostup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniya","family":"Kogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zaitsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Fomin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht210"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-2022-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.11.022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1180"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-011-9890-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086\/648074"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl525"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2012.02.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0026-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-016-4515-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.10.011"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:31:58Z","timestamp":1745425918000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,7,10]]},"published-print":{"date-parts":[[2019,7,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000499865","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}