{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:45:08Z","timestamp":1775706308683,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Objective:<\/i><\/b> To assess final adult height (FAH) in children with short stature treated with gonadotropin-releasing hormone analogue (GnRHa). <b><i>Methods:<\/i><\/b> All patients with idiopathic short stature (ISS) with normally timed puberty and a Tanner stage between 2 and 3, who achieved their FAH between 2005 and 2015, were included in this clinical historical cohort study. Height gain, FAH, and mid-parental height of 28 children with ISS who received GnRHa treatment for 1.8 \u00b1 1.0 years to delay their puberty were compared to 31 untreated children. <b><i>Results:<\/i><\/b> The FAHs of the treated and the untreated girls were 151.3 \u00b1 5.1 and 146.8 \u00b1 3.8 cm (<i>p<\/i> = 0.01), respectively. The FAHs of the treated and the untreated boys were 156.4 \u00b1 4.7 and 152.3 \u00b1 5.7 cm (<i>p<\/i> = 0.111), respectively. The height gain in the treated and the untreated girls was 1.6 \u00b1 7.8 and \u20133.6 \u00b1 5.7 cm (<i>p<\/i> = 0.036), respectively. Height gain in the treated and the untreated boys was \u20135.1 \u00b1 13.6 and \u201311.5 \u00b1 8.4 cm (<i>p<\/i> = 0.171), respectively. <b><i>Conclusion:<\/i><\/b> GnRHa therapy has a modest effect in improving FAH in adolescent females with ISS but not in boys.<\/jats:p>","DOI":"10.1159\/000499929","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T21:00:34Z","timestamp":1566939634000},"page":"509-516","source":"Crossref","is-referenced-by-count":13,"title":["The Effect of Gonadotropin-Releasing Hormone Analogue on Final Adult Height in Children with Idiopathic Short Stature"],"prefix":"10.1159","volume":"28","author":[{"given":"Nahla","family":"Khawaja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala","family":"Owaineh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar","family":"Batieha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oraib","family":"Frahid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"EL-Khateeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-6306","authenticated-orcid":false,"given":"Kamel\u00a0M.","family":"Ajlouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153953"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.1982.tb00293.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2002.0211"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0509"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70117-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.145075"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.151u101"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2015.01.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000452150"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2007.11.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0590"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.74.2.1449545"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808273390905"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955894"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013555"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4158\/EP14412.OR"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2017.11.21187"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01829"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195909000-00030"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(52)80205-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020974"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0671"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.151s041"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:43Z","timestamp":1745425963000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,11,28]]},"published-print":{"date-parts":[[2019,12,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000499929","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}