{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:13:05Z","timestamp":1770747185765,"version":"3.49.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Renal function tends to deteriorate in a hyperchloremic acidifying environment, which is reflected by a decrease in the difference between sodium and chloride. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To examine the effect of furosemide administered under hyperchloremic acidosis on intraoperative oliguria and acute kidney injury in patients with preoperatively normal renal function. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In patients undergoing abdominal or orthopedic surgeries (April 2010\u2013November 2018), we retrospectively identified patients who preoperatively had a normal renal function but experienced intraoperative oliguria under hyperchloremic acidosis (a sodium-chloride difference &amp;#x3c; 30 mEq\/L) without dehydration. We compared the perioperative urine output and the incidence of postoperative acute kidney injury between patients who intraoperatively received an initial dose of 5 mg of furosemide (the furosemide group) and patients who did not intraoperatively receive furosemide (the control group). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We identified 62 patients in the furosemide group and 48 patients in the control group. The furosemide group intraoperatively received 0.11 \u00b1 0.06 mg\/kg of furosemide (range 0.06\u20130.39 mg\/kg). Compared to the control group, the furosemide group had greater urine output (mL\/kg\/h) in the operating room (1.1 \u00b1 0.7 vs. 0.3 \u00b1 0.1, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01) and on postoperative day 1 (1.2 \u00b1 0.5 vs. 1.1 \u00b1 0.4, &lt;i&gt;p&lt;\/i&gt; = 0.02). The incidence of postoperative acute kidney injury was lesser in the furosemide group than that in the control group (8.0 vs. 27.0%, &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01; multivariate OR 0.18; 95% CI 0.05\u20130.61; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In surgery patients under hyperchloremic acidosis, furosemide (0.1 mg\/kg) resolved intraoperative oliguria and reduced the incidence of postoperative acute kidney injury.<\/jats:p>","DOI":"10.1159\/000499938","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T21:02:21Z","timestamp":1555448541000},"page":"320-327","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Furosemide under Hyperchloremic Acidosis on Intraoperative Oliguria and Acute Kidney Injury in Patients with Normal Renal Function"],"prefix":"10.1159","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-6117","authenticated-orcid":false,"given":"Mutsuhito","family":"Kikura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Uraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,4,16]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:57Z","timestamp":1745425977000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,7,31]]},"published-print":{"date-parts":[[2019,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000499938","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}