{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:29:48Z","timestamp":1775075388135,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"2-6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervent Neurol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>First pass success (FPS) can be defined as in vitro retrieval of clot in a single pass during mechanical thrombectomy (MT) for acute large vessel occlusion (LVO). Despite advancements in MT technology, retrieval of fibrin-rich clots remains a challenge. Therefore, the effect of stent retriever length on FPS for fibrin-rich clots was investigated by using Solitaire&lt;sup&gt;TM&lt;\/sup&gt; 6 \u00d7 40 versus 6 \u00d7 30 mm devices with a balloon guide catheter (BGC) or distal access catheter (DAC) and sheath, in an in vitro model of anterior circulation neurovascular anatomy. Additionally, vascular safety of the Solitaire&lt;sup&gt;TM&lt;\/sup&gt; 6 \u00d7 40 versus 6 \u00d7 30 mm devices was evaluated in a porcine model for differences in: luminal thrombus, inflammation, endothelial coverage, fibrin deposits, smooth muscle cell loss, elastic lamina and adventitia disruption, intimal hyperplasia, and lumen reduction, at 0, 30, and 90 days post-treatment. In vitro overall FPS was measured as: Solitaire&lt;sup&gt;TM&lt;\/sup&gt; 6 \u00d7 40 (95%) and Solitaire&lt;sup&gt;TM&lt;\/sup&gt; 6 \u00d7 30 (67%). FPS for clot location in middle cerebral artery was: (a) BGC (6 \u00d7 40 mm: 100%; 6 \u00d7 30 mm: 100%; &lt;i&gt;n&lt;\/i&gt; = 8); (b) DAC with 088 sheath (6 \u00d7 40 mm: 83%; 6 \u00d7 30 mm: 33%; &lt;i&gt;n&lt;\/i&gt; = 12). FPS for clot location in internal carotid artery was: (a) BGC (6 \u00d7 40 mm: 100%; 6 \u00d7 30 mm: 80%; &lt;i&gt;n&lt;\/i&gt; = 11); (b) DAC with 088 sheath (6 \u00d7 40 mm: 100%; 6 \u00d7 30 mm: 67%; &lt;i&gt;n&lt;\/i&gt; = 10). Stent length had a significant effect (Fisher\u2019s exact test; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05) on FPS. In vivo evaluation in the porcine model showed no difference in vascular safety parameters between the Solitaire&lt;sup&gt;TM&lt;\/sup&gt; 6 \u00d7 40 and 6 \u00d7 30 mm devices (&lt;i&gt;p&lt;\/i&gt; &amp;#x3e; 0.05) at all time points in the study. Longer stent retrievers may be safe and effective in improving FPS for fibrin-rich clots in in vitro and in vivo models of LVO.<\/jats:p>","DOI":"10.1159\/000499974","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T21:00:33Z","timestamp":1560891633000},"page":"187-195","source":"Crossref","is-referenced-by-count":30,"title":["Longer 6-mm Diameter Stent Retrievers Are Effective for Achieving Higher First Pass Success with Fibrin-Rich Clots"],"prefix":"10.1159","volume":"8","author":[{"given":"Gaurav","family":"Girdhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejashri","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wainwright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amon\u00a0Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Italo","family":"Linfante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020315"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.605576"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012721"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013507"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012256"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011491"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3103"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000692"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011148"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4149"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011617"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011856"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-013918"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2485"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003079"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/159101991301900201"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3531"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000964"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012533"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.9644"}],"container-title":["Interventional Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/499974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:33:27Z","timestamp":1745426007000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000499974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":27,"journal-issue":{"issue":"2-6","published-online":{"date-parts":[[2020,1,21]]},"published-print":{"date-parts":[[2020,1,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000499974","archive":["Portico"],"relation":{},"ISSN":["1664-9737","1664-5545"],"issn-type":[{"value":"1664-9737","type":"print"},{"value":"1664-5545","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}