{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:32:18Z","timestamp":1788813138842,"version":"build-2803163510"},"reference-count":24,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Premenstrual syndrome (PMS) alludes to a cyclic advent of somatic and psychiatric symptoms that affect some women of reproductive age. Some studies demonstrated that vitamin D was associated with premenstrual symptoms. <b><i>Objective:<\/i><\/b> The aim of this study was to evaluate the effect of vitamin D supplementation in the treatment of PMS in vitamin D-deficient young girls. <b><i>Methods:<\/i><\/b> In this randomized double-blind placebo-controlled trial, 130 vitamin D-deficient girls aged 18\u201330 years, with PMS, were randomly divided into 2 groups and received a 2,000 IU vitamin D tablet (<i>n<\/i> = 64) or a placebo (<i>n<\/i> = 66) every other day for 12 weeks. At the beginning and at the end of week 12, serum 25(OH)-D, premenstrual symptoms, anthropometric indices, dietary intake, physical activity level, and sun exposure were evaluated. Statistical analysis was performed using SPSS version 20. <i>p<\/i> &#x3c; 0.05 was considered statistically significant. <b><i>Results:<\/i><\/b> Serum 25(OH)-D levels were significantly elevated in the vitamin D group in comparison to the placebo group after 12 weeks (<i>p<\/i> &#x3c; 0.001). There was no significant difference between the 2 groups with regard to 14 symptoms of PMS after 12 weeks of intervention, even after adjustment for the baseline values of anxiety, weeping, and hypersomnia (for all symptoms, <i>p<\/i> &#x3e; 0.05). However, in the vitamin D group, scores of nervousness (<i>p<\/i> &#x3c; 0.001), job activity reduction (<i>p<\/i> = 0.01), social activity reduction (<i>p<\/i> = 0.01), fatigue (<i>p<\/i> &#x3c; 0.001), and physical symptoms (<i>p<\/i> = 0.00) were reduced at the end of the intervention, and these changes were statistically significant compared to baseline. However, these alterations did not reach significance compared with the placebo group (<i>p<\/i> &#x3e; 0.05). <b><i>Conclusion:<\/i><\/b> It seems that 2,000 IU vitamin D consumption in the vitamin D-deficient young girls with PMS every other day for 12 weeks had no significant impact on other PMS symptoms.<\/jats:p>","DOI":"10.1159\/000500016","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T21:00:27Z","timestamp":1558126827000},"page":"336-342","source":"Crossref","is-referenced-by-count":23,"title":["The Effect of Vitamin D Supplement Consumption on Premenstrual Syndrome in Vitamin D-Deficient Young Girls: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial"],"prefix":"10.1159","volume":"26","author":[{"given":"Reihaneh","family":"Abdollahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Abiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvin","family":"Sarbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Kashanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Vafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2015.12.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.01.015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-14-56"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr482"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2009.00220.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0348-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.715"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1777"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31828acca0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2012.12.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-18"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.18869\/acadpub.nfsr.3.3.17"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9114210"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2010.03.076"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.01.016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2726"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90775-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70377-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.11.1246"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198706000-00017"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199209000-00019"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1136617"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1423466"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:33:44Z","timestamp":1745426024000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,10,31]]},"published-print":{"date-parts":[[2019,10,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000500016","archive":["Portico"],"relation":{},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"value":"2504-2092","type":"print"},{"value":"2504-2106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}