{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:43:17Z","timestamp":1769913797809,"version":"3.49.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Phoniatr Logop"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To compare symptoms, signs, and acoustical voice quality changes throughout the 6-month course of empirical treatment between laryngopharyngeal reflux (LPR) males and females. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Forty clinically diagnosed LPR females and 40 males with a reflux finding score (RFS) &amp;#x3e;7 and a reflux symptom index (RSI) &amp;#x3e;13 were treated with pantoprazole and diet recommendations during 3 or 6 months according to their evolution. RSI, RFS, and acoustic parameters were assessed at baseline and 3 and 6 months posttreatment. A correlation analysis between videolaryngostroboscopic findings and acoustic measurements was performed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; RSI, RFS, and many acoustic measurements (i.e., percent jitter, percent shimmer, phonatory fundamental frequency range, fundamental frequency variation, and peak-to-peak amplitude variation) significantly improved from baseline to 3 months posttreatment in male group. In female group, RSI and RFS total score significantly improved along the 3 first months of treatment. However, some clinical outcomes (i.e., RSI total score, hoarseness, cough, and globus) continued to improve from 3 to 6 months of treatment. We did not identify significant improvement of acoustic measurements in female group. The correlation study did not reveal significant correlation between videolaryngostroboscopic findings and acoustic measurements. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This preliminary study suggests the occurrence of gender-related differences in the LPR therapeutic response. Further studies need to clarify whether females require a longer course of therapy than males.<\/jats:p>","DOI":"10.1159\/000500085","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T21:01:27Z","timestamp":1558990887000},"page":"257-266","source":"Crossref","is-referenced-by-count":13,"title":["Clinical and Acoustical Voice Quality Evolutions Throughout Empirical Treatment for Laryngopharyngeal Reflux Disease According to Gender: A Preliminary Study"],"prefix":"10.1159","volume":"72","author":[{"given":"J\u00e9r\u00f4me\u00a0R.","family":"Lechien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Huet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Finck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Khalife","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Francoise","family":"Fourneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Harmegnies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181651c3a"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-3126-y"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24955"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200212000-00013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-4951-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000340046"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000408"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2016.11.020"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196811000-00007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-3984-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(98)80078-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(96)80033-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0171-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24911"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.10.009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1067\/S0892-1997(03)00078-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.01.016"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1473642"}],"container-title":["Folia Phoniatrica et Logopaedica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:34:17Z","timestamp":1745426057000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,27]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,7,17]]},"published-print":{"date-parts":[[2020,7,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000500085","archive":["Portico"],"relation":{},"ISSN":["1021-7762","1421-9972"],"issn-type":[{"value":"1021-7762","type":"print"},{"value":"1421-9972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,27]]}}}