{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:01Z","timestamp":1745468881531,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Investigate the role of Yes-associated protein (YAP1) in the development of condyloma acuminatum (CA). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We enrolled 30 male patients with CA and 20 healthy individuals as a control group, to compare the YAP1 expression in their tissue samples. Following this, we overexpressed and downregulated &lt;i&gt;YAP1&lt;\/i&gt; expression in HaCaT cells to examine the migratory, proliferative, and apoptotic potential of HaCaT cells expressing different levels of YAP1. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In the CA patient tissue samples, an increase in YAP1 expression can be observed. In vitro&lt;i&gt;,&lt;\/i&gt;the overexpression of YAP1 was shown to promote the growth and migration of HaCaT cells and to activate epidermal growth factor receptor (EGFR) pathway-associated proteins, while the downregulation of YAP1 inhibited cell growth and migration of these cells. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; YAP1 promotes the growth of keratinocytes in CA through the activation of the EGFR pathway, and it may mediate the development of human papilloma virus-associated diseases.<\/jats:p>","DOI":"10.1159\/000500216","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T21:00:31Z","timestamp":1568408431000},"page":"454-466","source":"Crossref","is-referenced-by-count":2,"title":["Yes-Associated Protein Promotes the Development of Condyloma Acuminatum through EGFR Pathway Activation"],"prefix":"10.1159","volume":"236","author":[{"given":"Zhenghui","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lishi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhili","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingjiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30343-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf2527"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.05.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1242\/dev.133728"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.12.017"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404976"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13428"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120790"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4319"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32522-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.02.005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02126.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.59"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.045"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1420850112"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:35:43Z","timestamp":1745426143000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,13]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,9,2]]},"published-print":{"date-parts":[[2020,9,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000500216","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.9821279","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2019,9,13]]}}}