{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:05:33Z","timestamp":1761663933275,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> The natural history and optimal management of a patent ductus arteriosus (PDA) among infants with established severe bronchopulmonary dysplasia (sBPD) remains uncertain. <b><i>Objectives:<\/i><\/b> To describe the characteristics of PDA present at \u226536 weeks\u2019 postmenstrual age (PMA) and the effects of late surgical PDA closure in a referral cohort of very preterm infants with sBPD. <b><i>Study Design:<\/i><\/b> This retrospective cohort study was performed in a tertiary neonatal intensive care unit. Study infants were born at &#x3c;32 weeks\u2019 gestation between 2010 and 2016, diagnosed with sBPD, and had an echocardiographic PDA at \u226536 weeks\u2019 PMA. We reviewed echocardiograms performed closest to 3 time points (\u226536 weeks\u2019 PMA, hospital discharge, and 1 year of age) and assessed clinical outcomes among infants with versus without late PDA treatment. <b><i>Results:<\/i><\/b> Among 329 infants with sBPD, 59 had a PDA at \u226536 weeks\u2019 PMA. Most PDAs were small (<i>n<\/i> = 33) and shunted left to right (<i>n<\/i> = 53). The PDA closed spontaneously prior to discharge in 5 of 21 infants who did not undergo surgical closure and decreased in size in 3. The PDA spontaneously closed by 1 year of age in 6 out of 12 infants with an open duct at discharge. PDA surgery (<i>n<\/i> = 23) at \u226536 weeks\u2019 PMA was not associated with increased risk for the composite outcome of tracheostomy, systemic vasodilator at discharge, or death after adjusting for potential confounders (OR 3.2, 95% CI 0.81\u201313.0). <b><i>Conclusions:<\/i><\/b> The majority of conservatively treated late PDAs closed spontaneously or decreased in size.<b><i><\/i><\/b>PDA surgery was not associated with severe adverse clinical outcomes.<\/jats:p>","DOI":"10.1159\/000500269","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T21:00:31Z","timestamp":1562187631000},"page":"236-243","source":"Crossref","is-referenced-by-count":8,"title":["Patent Ductus Arteriosus and the Effects of Its Late Closure in Preterm Infants with Severe Bronchopulmonary Dysplasia"],"prefix":"10.1159","volume":"116","author":[{"given":"Sophia\u00a0M.","family":"Ansems","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haresh","family":"Kirpalani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mercer-Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel\u00a0K.","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u00a0V.","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik\u00a0A.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23235"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70362-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80746-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295646"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.6.1345"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.01.047"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.01.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1593351"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2390"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.024"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.06.032"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.129270"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.104596"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.08.023"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.09.022"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42693"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2781"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906083202302"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306214"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3431"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-016-0552-7"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:36:10Z","timestamp":1745426170000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,10,8]]},"published-print":{"date-parts":[[2019,10,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000500269","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2019]]}}}