{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:19:05Z","timestamp":1787501945441,"version":"build-2736575974"},"reference-count":0,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Our study investigated the therapeutic role and potential mechanisms of pterostilbene (PS) in diabetic nephropathy (DN) rats. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; DN models were established by high-fat diet after streptozotocin injection. A total of 50 Sprague-Dawley rats were randomly divided into control, DN, PS-treated groups (PS-H, PS-M, PS-L). PS was administered to rats by gavage for 8 weeks at 3 different doses (25, 10, and 5 mg\/kg\/day). The levels of oxidative stress activity (superoxide dismutase [SOD], malondialdehyde [MDA], glutathione peroxidase [GSH-PX]) and inflammatory factors (tumor necrosis factor [TNF]-\u03b1, interleukin (IL)-6, IL-1\u03b2, monocyte chemoattractant factor [MCP]-1) were detected by \u00adELISA. TGF-\u03b2, Smad1, and fibronectin (FN) were measured through immunohistochemistry. The relative expressions of phospho-I\u03baB\u03b1\/I\u03baB\u03b1, phospho-I\u03baB kinases (IKK)\u03b2\/IKK\u03b2, phospho-nuclear factor-\u03baB (NF-\u03baB) p65\/NF-\u03baB p65 were detected by western blot. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Compared with DN group, the levels of TNF-\u03b1, IL-6, IL-1\u03b2, and MCP-1 were decreased in the PS-H group (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). Meanwhile, the levels of SOD, MDA, GSH-PX improved in kidney and serum in PS-H groups (&lt;i&gt;p&lt;\/i&gt;&amp;#x3c;\u00a00.05). PS also significantly decreased the level of phospho-NF-\u03baB p65 and increased the levels of phospho- IKK\u03b2 and phospho-I\u03ba-B\u03b1 (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.05). The results showed that PS treatment decreased TGF-\u03b2, Smad1, and FN expressions. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; PS had potential therapeutic effects on DN, which may be related to the regulation of NF-\u03baB pathway.<\/jats:p>","DOI":"10.1159\/000500293","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T17:02:50Z","timestamp":1558544570000},"page":"71-80","source":"Crossref","is-referenced-by-count":14,"title":["Pterostilbene Ameliorates Nephropathy Injury in Streptozotocin-Induced Diabetic Rats"],"prefix":"10.1159","volume":"104","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,5,22]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:36:21Z","timestamp":1745411781000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":0,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2019,6,14]]},"published-print":{"date-parts":[[2019,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000500293","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}