{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:21:29Z","timestamp":1769214089800,"version":"3.49.0"},"reference-count":43,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Growing evidence has reported that a history of preeclampsia (PE) increases the risk of developing cardiovascular disease (CVD). Arterial stiffness plays a predictive role in CVD. Previous studies have demonstrated the close association between homocysteine (Hcy) level and arterial stiffness in community-based populations. This study was to assess whether Hcy level was independently associated with arterial stiffness in 168 women with a PE history who were analyzed at a 5-year follow-up. Brachial-ankle pulse wave velocity (baPWV) was measured by an automatic pulse-wave analyzer and a value &amp;#x3e;1,400 cm\/s was defined as high arterial stiffness. Biochemical parameters were recorded and an Hcy value &amp;#x3e;10 \u03bcmol\/L was defined as having hyperhomocysteine (H-Hcy). Variables that were significantly associated with baPWV were tested for independence by multivariate logistic regression analysis. We found that body mass index (OR 1.017, 95% CI 1.008\u20131.029), systolic blood pressure (OR 1.048, 95% CI 1.019\u20131.072), total cholesterol (OR 1.059, 95% CI 1.007\u20131.086), and Hcy level (OR 1.021, 95% CI 1.010\u20131.037) were independent determinants of baPWV in women with previous PE. Our findings indicate that Hcy pathway might be involved in arterial stiffness in women with a PE history. Whether Hcy would be a promising biomarker for serial stratified CVD risk management in these women deserves further evaluation on a large scale.<\/jats:p>","DOI":"10.1159\/000500358","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T21:01:27Z","timestamp":1558990887000},"page":"152-159","source":"Crossref","is-referenced-by-count":5,"title":["Association between Homocysteine and Arterial Stiffness in Women with a History of 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