{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:46:49Z","timestamp":1754261209447,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiorenal Med"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background and Objectives:<\/i><\/b> Cyst pressure induces renin-angiotensin-aldosterone system activation and kidney hypoxia in autosomal dominant polycystic kidney disease (ADPKD). Lipopolysaccharide-induced Toll-like receptor activation causes metabolic disturbances that are triggered by increased succinate levels and hypoxia inducible factors, which results in inflammation via <i>IL-1\u03b2<\/i> activation. Since we aimed to investigate the role of both inflammation and hypoxia in the clinical course of ADPKD, via succinate levels from sera samples, <i>HIF-1\u03b1<\/i> gene expression from whole blood and urine samples and <i>IL-1\u03b2<\/i>gene expression from whole blood were measured. <b><i>Methods:<\/i><\/b> One hundred ADPKD patients and 100 matched healthy controls were enrolled to this cross-sectional study. Twenty-four-hour ambulatory blood pressure monitoring was conducted in all participants. Blood, serum, and urine samples were taken after 12-h fasting for the measurement of biochemical parameters and succinate levels. Whole blood and urine samples were used for <i>HIF-1\u03b1<\/i> and <i>IL-1\u03b2<\/i> gene<i><\/i>expression by using quantitative real-time PCR. <b><i>Results:<\/i><\/b> There were significant differences in whole blood <i>HIF-1\u03b1<\/i>,<i> IL-1\u03b2<\/i> gene<i><\/i>expression, and serum<i><\/i>succinate levels between the ADPKD patients and the control subjects. Whole blood <i>HIF-1\u03b1<\/i>gene expression,<i> IL-1\u03b2<\/i> gene<i><\/i>expression, and serum<i><\/i>succinate levels were also significantly different in ADPKD patients with hypertension in comparison with normotensive ones (<i>p<\/i> &#x3c; 0.05). Serum succinate levels and blood<i> IL-1\u03b2<\/i> gene<i><\/i>expression were increased in ADPKD patients with high levels of <i>HIF-1\u03b1 gene<\/i>expression (<i>p<\/i> = 0.018 and <i>p<\/i> = 0.029, respectively). <b><i>Conclusions:<\/i><\/b> Increased age,<i><\/i>low eGFR, and <i>HIF-1\u03b1<\/i> and <i>IL-1\u03b2<\/i> gene<i><\/i>expressions were also independently associated with hypertension in ADPKD patients. Inflammation and hypoxia are both relevant factors that might be associated with hypertension in ADPKD.<\/jats:p>","DOI":"10.1159\/000500478","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T21:00:28Z","timestamp":1563483628000},"page":"370-381","source":"Crossref","is-referenced-by-count":10,"title":["Systemic Succinate, Hypoxia-Inducible Factor-1 Alpha, and IL-1\u03b2 Gene Expression in Autosomal Dominant Polycystic Kidney Disease with and without Hypertension"],"prefix":"10.1159","volume":"9","author":[{"given":"Ismail","family":"Kocyigit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eray","family":"Eroglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif\u00a0Funda","family":"Sener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokmen","family":"Zarars\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilknur","family":"Uzun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Tufan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ecmel","family":"Mehmetbeyoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kezban","family":"Korkmaz\u00a0Bayramov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat\u00a0Hayri","family":"Sipahioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Ozkul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Tokgoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"Oymak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Axelsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.01.011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04140510"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000121781.89599.16"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.91"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2014.5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.486464"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12458"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-014-0045-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/837421"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000060"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05578"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00348.2010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90209.2008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060455"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013030209"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008050507"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.0525144"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.4.613"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90203-D"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00264.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2174\/1573402111309010002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.195"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.330"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000354317"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00419.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000441049.98664.6c"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.9.5804"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.06.008"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901698"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-249540"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986"}],"container-title":["Cardiorenal 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