{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:31:40Z","timestamp":1788989500519,"version":"build-2803163510"},"reference-count":30,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":2428,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objectives: The aims of this study were to report the risk of thyroid malignancy in cases of either benign fine-needle aspiration (FNA) or without FNA performed, and to investigate possible predictive factors for thyroid malignancy in a population with recent moderately low iodine intake. Methods: All patients referred for thyroid surgery in a tertiary cancer centre between 2000 and 2016 were included (n = 3,703). After excluding cases indicating malignant histology, we included group 1: patients with benign FNA (n = 764), and group 2: patients without FNA (n = 740), leaving 1,504 eligible for further investigation. Information on age, gender, tracheal compression or dislocation, thyroid specimen weight, scintigraphy, ultrasound, medically treated thyrotoxicosis, serum stimulating thyroid hormone, indication for surgery, TNM classification, stage, and outcome were retrieved. Results: The malignancy risk was 7.6% (58\/764) in group 1 and 6.8% (50\/740) in group 2. Patients with T2\u20134 tumours constituted 2.2% (33\/1,504). In the combined groups, ultrasound verified that solitary solid tumour was predictive for malignancy (p = 0.01 by \u03c7&amp;lt;sup&amp;gt;2&amp;lt;\/sup&amp;gt;, and OR = 1.69, p = 0.02 in multiple logistic regression). For group 1 patients, thyrotoxicosis (which in this case was medically treated) was a significant predictive factor for malignancy (p = 0.04). Conclusions: The risk of malignancy of 7.6% and 6.8% was high, considering that patients with malignant FNA, suspicious FNA, or clinical findings indicating malignancy were excluded, and 2.2% of these malignancies were stages T2\u20134. In cases with solitary solid tumour on ultrasound, the risk of malignancy should not be ignored, even with benign FNA.<\/jats:p>","DOI":"10.1159\/000500539","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T17:00:30Z","timestamp":1563382830000},"page":"246-255","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":4,"title":["Risk of Thyroid Cancer in 1,504 Patients Referred for Thyroid Surgery with Assumed Benign Histology"],"prefix":"10.1530","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-6143","authenticated-orcid":false,"given":"Signe\u00a0Buhl","family":"Gram","sequence":"first","affiliation":[{"name":"1Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob\u00a0H\u00f8ygaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"1Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[{"name":"2Department of Medical Endocrinology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bentzen","sequence":"additional","affiliation":[{"name":"3Department of Oncology, Herlev Hospital, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giedrius","family":"Lelkaitis","sequence":"additional","affiliation":[{"name":"4Department of Pathology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"von\u00a0Buchwald","sequence":"additional","affiliation":[{"name":"1Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer\u00a0Holst","family":"Hahn","sequence":"additional","affiliation":[{"name":"1Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"2026070712591957100_ref1","doi-asserted-by":"crossref","unstructured":"Blomberg\n              M\n            , Feldt-RasmussenU, AndersenKK, KjaerSK. Thyroid cancer in Denmark 1943\u20132008, before and after iodine supplementation. 2012;2366:2360\u20136.","DOI":"10.1002\/ijc.27497"},{"issue":"March","key":"2026070712591957100_ref2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.canep.2018.05.009","article-title":"Trends in thyroid cancer: retrospective analysis of incidence and survival in Denmark 1980-2014","volume":"55","author":"Mirian","year":"2018","journal-title":"Cancer Epidemiol","ISSN":"https:\/\/id.crossref.org\/issn\/1877-7821","issn-type":"print"},{"key":"2026070712591957100_ref3","doi-asserted-by":"publisher","first-page":"965212","DOI":"10.1155\/2013\/965212","article-title":"Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors","volume":"2013","author":"Pellegriti","year":"2013","journal-title":"J Cancer Epidemiol","ISSN":"https:\/\/id.crossref.org\/issn\/1687-8558","issn-type":"print"},{"issue":"1","key":"2026070712591957100_ref4","first-page":"78","volume":"25","author":"Londero","year":"2015","journal-title":"Outcome and Evaluation of Established Prognostic Scoring Systems in a Prospective National Cohort."},{"issue":"5","key":"2026070712591957100_ref5","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s00405-013-2584-z","article-title":"A \u201cpackage solution\u201d fast track program can reduce the diagnostic waiting time in head and neck cancer","volume":"271","author":"Sorensen","year":"2014","journal-title":"Eur Arch Otorhinolaryngol","ISSN":"https:\/\/id.crossref.org\/issn\/0937-4477","issn-type":"print"},{"issue":"2","key":"2026070712591957100_ref6","first-page":"1","article-title":"Risk of malignancy in fine-needle aspiration biopsy in patients with thyroid nodules","volume":"64","author":"Egset","year":"2017","journal-title":"Dan Med J","ISSN":"https:\/\/id.crossref.org\/issn\/2245-1919","issn-type":"print"},{"issue":"9","key":"2026070712591957100_ref7","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1002\/hed.20849","article-title":"Fine-needle aspiration cytology in a regional head and neck cancer center: comparison with a systematic review and meta-analysis","volume":"30","author":"Tandon","year":"2008","journal-title":"Head Neck","ISSN":"https:\/\/id.crossref.org\/issn\/1043-3074","issn-type":"print"},{"issue":"1","key":"2026070712591957100_ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"6","key":"2026070712591957100_ref9","article-title":"Occult papillary carcinoma of the thyroid. 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