{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:15:19Z","timestamp":1791908119302,"version":"4.3.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Bacteriophages (phages) are viruses of bacteria. &lt;i&gt;Escherichia coli&lt;\/i&gt; phage (T4) can potentially interfere with adsorption of HAdV-5 to cellular integrins by its KGD motif, while staphylococcal A5\/80 phage does not possess this structure. The objective of this study was to investigate the effects of T4 and A5\/80 phage preparations on type 5 human adenovirus (HAdV-5) DNA synthesis and the expression of HAdV-5 genes. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Experiments were performed on the A549 cell line. HAdV-5 DNA synthesis was investigated with real-time PCR. Expression of HAdV-5 early (DBP) and late (hexon) genes was determined by quantitative real-time PCR in preincubation and coincubation experiments. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; While both phage preparations significantly reduced the expression of HAdV-5 genes, synthesis of HAdV-5 DNA was inhibited only by T4. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Phage preparations show promise as novel antiviral agents. However, further studies are required to investigate their antiviral effects.<\/jats:p>","DOI":"10.1159\/000500540","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T21:00:34Z","timestamp":1560373234000},"page":"37-44","source":"Crossref","is-referenced-by-count":8,"title":["Inhibitory Effects of Bacteriophage Preparations on Adenoviral Replication"],"prefix":"10.1159","volume":"62","author":[{"given":"Maciej","family":"Przybylski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Dzieci\u0105tkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Borysowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard","family":"Mi\u0119dzybrodzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"G\u00f3rski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01515"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.01.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-120-30603"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/220822a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1991.11.271"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190504"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(96)00951-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.147"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90231-E"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/v11010010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2013.0128"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2015.04.023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1969.tb00601.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-4-210"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-S2-S11"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394438-2.00005-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-05597-7_5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1038"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/cells1030646"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500540","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:38:31Z","timestamp":1745426311000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,7,18]]},"published-print":{"date-parts":[[2019,7,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000500540","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}