{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:47:08Z","timestamp":1775058428848,"version":"3.50.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Care"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The main side effects of tamoxifen are menopausal symptoms. We report a case of agranulocytosis induced by tamoxifen in a 33-year-old woman treated in the adjuvant setting. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; Ten days after the beginning of tamoxifen treatment, the patient complained of asthenia and mucositis. Blood testing showed a grade 4 neutropenia (0.06 G\/L) without any other major hematologic disorder. Tamoxifen was discontinued, and the patient received granulocyte colony-stimulating factor. Within 2 days, she recovered to a normal granulocyte count. Tamoxifen was then switched to the combination of ovarian suppression (triptorelin) and aromatase inhibitor (anastrozole). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Agranulocytosis is a very rare adverse event of tamoxifen.<\/jats:p>","DOI":"10.1159\/000500708","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T21:01:05Z","timestamp":1561064465000},"page":"72-74","source":"Crossref","is-referenced-by-count":9,"title":["Agranulocytosis Induced by Tamoxifen in a Breast Cancer Patient"],"prefix":"10.1159","volume":"15","author":[{"given":"Hugo","family":"Herrscher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Leblanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Petit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60993-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.05.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404037"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412379"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08104.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003301"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2007.01.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1376645"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1078155213487394"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91929-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-58-696-1220"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90991-B"}],"container-title":["Breast Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:13Z","timestamp":1745426413000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,2,18]]},"published-print":{"date-parts":[[2020,3,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000500708","archive":["Portico"],"relation":{},"ISSN":["1661-3791","1661-3805"],"issn-type":[{"value":"1661-3791","type":"print"},{"value":"1661-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]}}}