{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:08:22Z","timestamp":1759615702812,"version":"3.40.5"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Significant evidence from various sources suggests that structural alterations in mitochondrial function may play a role in both the pathogenesis of mood disorders and the therapeutic effects of available treatments. PGC-1\u03b1 is a distinct transcriptional regulator designed to mediate the synchronous release of neurotransmitter in the brain and thereby to coordinate a number of gene expression pathways to promote mitochondrial biogenesis and oxidative phosphorylation. The role of PGC-1\u03b1 in the context of affective disorder phenotypes and treatments has been suggested but not studied in depth. To further investigate the possible involvement of PGC-1\u03b1 in affective disorders, we generated conditional PGC-1\u03b1 null mice through transgenic expression of cre recombinase under the control of a Dlx5\/6 promoter; cre-mediated excision events were limited to \u03b3-amino-butyric-acid (GABA)-ergic specific neurons. We tested these mice in a battery of behavioral tests related to affective change including spontaneous activity, elevated plus maze, forced swim test, and tail suspension test. Results demonstrated that mice lacking PGC-1\u03b1 in GABAergic neurons exhibited increased activity across tests that might be related to a mania-like phenotype. These results suggest possible relevance of PGC-1\u03b1 to affective change, which corresponds with data connecting mitochondrial function and affective disorders and their treatment.<\/jats:p>","DOI":"10.1159\/000500738","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T21:00:38Z","timestamp":1562101238000},"page":"182-188","source":"Crossref","is-referenced-by-count":10,"title":["Mice Lacking the Transcriptional Coactivator PGC-1\u03b1 Exhibit Hyperactivity"],"prefix":"10.1159","volume":"78","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Jun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Rong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel\u00a0Eguasi","family":"Inkabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-Jing\u00a0","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Mei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ning\u00a0","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-5541","authenticated-orcid":false,"given":"Haim","family":"Einat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795164086"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.194"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-015-0222-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.01.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03961-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301850200"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100631200"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.09.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12993-016-0101-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05809.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.06.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12306"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21211"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.1047"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-1133X(1001)00225-00221"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr2300"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2010_49"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32086"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.013"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01258-X"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2015.1053"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-00013-01594-x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000059"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:26Z","timestamp":1745426426000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2019,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000500738","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[2019]]}}}