{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:22:35Z","timestamp":1772608955499,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Burn injury leads to a hypercatabolic response and ultimately muscle wasting with drastic implications for recovery of bodily functions, patient\u2019s quality of life (QoL), and long-term survival. Several treatment options target the body\u2019s initial stress response, but pharmacological approaches to specifically address muscle protein metabolism have only been poorly investigated. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to assess the role of myostatin and follistatin in burn injury and its possible implications in muscle wasting syndrome. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We harvested serum from male patients within 48 h and again 9\u201312 months after severe burn injury (&amp;#x3e;20% of total body surface area). By means of myoblast cultures, immunohistochemistry, immunoblotting, and scratch assay, the role of myostatin and its implications in post-burn muscle metabolism and myoblast proliferation and differentiation was analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; We were able to show increased proliferative and myogenic capacity, decreased myostatin, decreased SMAD 2\/3, and elevated follistatin concentrations in human skeletal myoblast cultures with serum conditioned medium of patients in the acute phase of burn injury and conversely a reversed situation in patients in the chronic phase of burn injury. Thus, there is a biphasic response to burn trauma, initiated by an anabolic state and followed by long-term hypercatabolism. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; We conclude that the myostatin signaling pathway plays an important regulative role in burn-associated muscle wasting and that blockade of myostatin could prove to be a valuable treatment approach improving the rehabilitation process, QoL, and long-term survival after severe burn injury.<\/jats:p>","DOI":"10.1159\/000500760","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T21:00:55Z","timestamp":1562965255000},"page":"86-96","source":"Crossref","is-referenced-by-count":11,"title":["Myostatin Upregulation in Patients in the Chronic Phase of Severe Burn Injury Leads to Muscle Cell Catabolism"],"prefix":"10.1159","volume":"60","author":[{"given":"Christoph","family":"Wallner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julika","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Drysch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja\u00a0Verena","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes\u00a0Maximilian","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Dadras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Lehnhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Behr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31469-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.05.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2009.05.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10404-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6500"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2012.09.028"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4318"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01970.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3791\/55047"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-12-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.04.018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00469.2004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18330"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0686-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20680"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.226001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.10.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.108059"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e32834bddf9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.123"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069525"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0849fje"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:35Z","timestamp":1745426435000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":23,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2019,7,31]]},"published-print":{"date-parts":[[2019,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000500760","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}