{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:32:37Z","timestamp":1745857957439,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objective:<\/i><\/b> Mean uterine artery pulsatility index (meanUAPI) is commonly measured at 11\u201313<sup>+6<\/sup> weeks to predict adverse pregnancy outcomes including hypertensive disorders and small-for-gestational age. The aims of this study were to establish a population-specific reference range for meanUAPI at &#x3c;11 weeks, to determine if an abnormal meanUAPI at &#x3c;11 weeks was associated with adverse pregnancy outcome, and to assess changes in meanUAPI between &#x3c;11 weeks and 11\u201313<sup>+6<\/sup> weeks. <b><i>Methods:<\/i><\/b> A prospective cohort was examined at &#x3c;11 weeks and at 11\u201313<sup>+6<\/sup> weeks to develop reference ranges for meanUAPI. Based on these regression models, meanUAPI Z-scores were compared between outcome groups using a two-sample <i>t<\/i> test. Longitudinal changes in the meanUAPI between &#x3c;11 and 11\u201313<sup>+6<\/sup> weeks were assessed by two-way mixed ANOVA. <b><i>Results:<\/i><\/b> Prior to 11 weeks, there was no significant difference in meanUAPI between normal (<i>n<\/i> = 622) and adverse (<i>n<\/i> = 80) outcomes (mean [95% CI]: 2.62 [2.57\u20132.67] and 2.67 [2.50\u20132.84], respectively; <i>p<\/i> = 0.807). At 11\u201313<sup>+6<\/sup> weeks, meanUAPI was significantly higher in the adverse (<i>n<\/i> = 66) compared with the normal (<i>n<\/i> = 535) outcome group (mean [95% CI]: 1.87 [1.70\u20132.03] and 1.67 [1.63\u20131.72], respectively; <i>p<\/i> = 0.040). There was a statistically significant decrease (<i>p<\/i> &#x3c; 0.0001) in meanUAPI between the two time points. <b><i>Conclusion:<\/i><\/b> MeanUAPI measured at &#x3c;11 weeks\u2019 gestation does not appear to be a useful marker for the prediction of placental-related adverse pregnancy outcomes, supporting an argument for the prediction of risk at 11\u201313<sup>+6<\/sup> weeks\u2019 gestation.<\/jats:p>","DOI":"10.1159\/000500776","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T21:00:33Z","timestamp":1562360433000},"page":"129-137","source":"Crossref","is-referenced-by-count":6,"title":["Uterine Artery Pulsatility Index Assessment at &#x3c;11 Weeks\u2019 Gestation: A Prospective Study"],"prefix":"10.1159","volume":"47","author":[{"given":"Tracey\u00a0J.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann\u00a0E.","family":"Quinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley\u00a0S.","family":"de\u00a0Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathon\u00a0A.","family":"Hyett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000266983.77458.71"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2007.11.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200606000-00010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.055"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/08035250600714326"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/03014460902980295"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200606000-00009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2012.11.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.035"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.07.025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.10.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/679730"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00572.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1976"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-477"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5157"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00594.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3881"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14819"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e9322a"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2010.506232"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100502"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90090-7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000475662"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13275"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00596.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000361021"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2016.04.009"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/500776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:41Z","timestamp":1745426441000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000500776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,5]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,4]]},"published-print":{"date-parts":[[2020,2,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000500776","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2019,7,5]]}}}