{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:35:26Z","timestamp":1790386526501,"version":"4.1.0"},"reference-count":37,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Neprilysin (NEP) cleaves amyloid-\u03b2 1\u201342 (A\u03b2&lt;sub&gt;42&lt;\/sub&gt;) in the brain. Hence, we aimed to elucidate the effect of NEP on A\u03b2&lt;sub&gt;42&lt;\/sub&gt; in cerebrospinal fluid (CSF) and on in vivo brain amyloid load using amyloid positron emission tomography (PET) with [&lt;sup&gt;11&lt;\/sup&gt;C]PiB (Pittsburgh compound B). In addition, associations with the biomarkers for neuronal injury, CSF-tau and FDG-PET, were investigated. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Associations were calculated using global and voxel-based (SPM8) linear regression analyses in the same cohort of 23 highly characterized Alzheimer\u2019s disease patients. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; CSF-NEP was significantly inversely associated with CSF-A\u03b2&lt;sub&gt;42&lt;\/sub&gt; and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer\u2019s pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration.<\/jats:p>","DOI":"10.1159\/000500811","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T21:00:38Z","timestamp":1562101238000},"page":"43-50","source":"Crossref","is-referenced-by-count":12,"title":["Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer\u2019s 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