{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:58:52Z","timestamp":1787313532066,"version":"build-2736575974"},"reference-count":49,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Objective:<\/i><\/b> To evaluate a dual-imaging modality approach to obtain a combined estimation of venous blood oxygenation (S<i>\u03bdO<\/i><sub>2<\/sub>) using susceptibility-weighted magnetic resonance imaging (SWI-MRI), and blood perfusion using power Dopp\u00adler ultrasound (PDU) and fractional moving blood volume (FMBV) in the brain of normal growth and growth-restricted fetuses. <b><i>Methods:<\/i><\/b> Normal growth (<i>n<\/i> = 33) and growth-restricted fetuses (<i>n<\/i> = 10) from singleton pregnancies between 20 and 40 weeks of gestation were evaluated. MRI was performed and S<i>\u03bdO<\/i><sub>2<\/sub> was calculated using SWI-MRI data obtained in the straight section of the superior sagittal sinus. Blood perfusion was estimated using PDU and FMBV from the frontal lobe in a mid-sagittal plane of the fetal brain. The association between fetal brain S<i>\u03bdO<\/i><sub>2<\/sub> and FMBV, and the distribution of S<i>\u03bdO<\/i><sub>2<\/sub> and FMBV values across gestation were calculated for both groups. <b><i>Results:<\/i><\/b> In growth-restricted fetuses, the brain S<i>\u03bdO<\/i><sub>2<\/sub> values were similar, and the FMBV values were higher across gestation as compared to normal growth fetuses. There was a significantly positive association between S<i>\u03bdO<\/i><sub>2<\/sub> and FMBV values (slope = 0.38 \u00b1 0.12; <i>r<\/i> = 0.7; <i>p<\/i> = 0.02) in growth-restricted fetuses. In normal growth fetuses, S<i>\u03bdO<\/i><sub>2<\/sub> showed a mild decreasing trend (slope = \u20130.7 \u00b1 0.4; <i>p<\/i> = 0.1), whereas FMBV showed a mild increasing trend (slope = 0.2 \u00b1 0.2; <i>p<\/i> = 0.2) with advancing gestation, and a mild but significant negative association (slope = \u20130.78 \u00b1 0.3; <i>r<\/i> = \u20130.4; <i>p<\/i> = 0.04) between these two estimates. <b><i>Conclusion:<\/i><\/b> Combined MRI (SWI) and ultrasound (FMBV) techniques showed a significant association between cerebral blood oxygenation and blood perfusion in normal growth and growth-restricted fetuses. This dual-imaging approach could contribute to the early detection of fetal \u201cbrain sparing\u201d and brain oxygen saturation changes in high-risk pregnancies.<\/jats:p>","DOI":"10.1159\/000500954","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T17:00:33Z","timestamp":1569258033000},"page":"145-155","source":"Crossref","is-referenced-by-count":9,"title":["Dual-Imaging Modality Approach to Evaluate Cerebral Hemodynamics in Growth-Restricted Fetuses: Oxygenation and 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