{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:15:56Z","timestamp":1792372556641,"version":"4.4.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; We aimed to analyze for the first time in Morocco the integrase (IN) sequence variability among highly experienced HIV-1-infected patients with no prior IN strand transfer inhibitor (INSTI) exposure who failed on reverse transcriptase inhibitors and protease inhibitors. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The HIV-1 IN region was sequenced from plasma samples of all 78 recruited patients. The amino acid IN sequences were HIV-1 subtyped and screened for the presence of polymorphisms against the HxB2 clade B consensus sequence by the geno2pheno subtyping tool and interpreted for drug resistance according to the Stanford algorithm. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The viral subtypes were subtype B (88.4%), CRF02_AG (8.9%), CRF01_AE (1.28%), and subtype C (1.28%). The major INSTI resistance mutations at positions 66, 92, 118, 138, 140, 143, 147, 148, 155, and 263 were absent, while two accessory mutations, L74M\/I, known to have no clinical impact to INSTIs in the absence of the major resistance mutations, were detected in three samples (3.84%; two CRF02_AG and one CRF01_AE). Others specific substitutions with an uncertain role on the HIV-1 susceptibility to INSTIs at positions 72, 101, 119, 124, 156, 165, 193, 201, 203, 206, 230, 232, and 249 were found to be relatively common. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This study demonstrated that INSTIs should be an excellent alternative for salvage therapy in highly experienced patients with multidrug resistant viruses in Morocco.<\/jats:p>","DOI":"10.1159\/000501016","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T21:00:34Z","timestamp":1563224434000},"page":"65-71","source":"Crossref","is-referenced-by-count":6,"title":["HIV-1 Integrase Resistance among Highly Antiretroviral Experienced Patients from Morocco"],"prefix":"10.1159","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3546-5070","authenticated-orcid":false,"given":"Najwa","family":"Alaoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moulay\u00a0Abdelaziz","family":"El\u00a0Alaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"El\u00a0Annaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima\u00a0Zahra","family":"Farissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine\u00a0Sana\u00e2","family":"Alaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmostapha","family":"El\u00a0Fahime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad\u00a0","family":"Mrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.8900"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.1075393"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-25"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01228-07"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01075-09"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00470-08"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00157-11"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt220"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01209-10"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06591-11"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000199"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-22"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku199"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00397-09"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086\/503914"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1310\/4R1B-8F60-B57H-0ECN"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2007.00533.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq350"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181c9c967"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.247"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp423"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2008.0236"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01535-07"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-5-74"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-12"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq326"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv243"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000484692"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir025"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis750"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.06.012"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:43:29Z","timestamp":1745426609000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,8,29]]},"published-print":{"date-parts":[[2019,9,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000501016","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}