{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:12:05Z","timestamp":1784365925243,"version":"3.55.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Fluid and magnesium abnormalities are common in patients with high-output stomas. Subcutaneous magnesium administration may be more feasible for long-term management in ambulatory patients, but magnesium sulfate is approved only for intravenous or intramuscular injection. We describe the management of chronic hypomagnesemia and dehydration secondary to a high-output ileostomy following radiation and chemotherapy for anal squamous cell carcinoma with intermittent home-based subcutaneous magnesium infusions in a 61-year-old female with a history of Crohn\u2019s disease and multiple bowel resections. Despite aggressive management with intravenous magnesium sulfate and oral magnesium glucoheptonate over 8 months, 49% of her magnesium concentrations were &amp;#x3c;0.60 mmol\/L (mean 0.61 \u00b1 0.09) necessitating 4 emergency, 1 hospital, and 4 infusion clinic visits. After initiation of subcutaneous magnesium sulfate, all magnesium concentrations were &amp;#x3e;0.60 mmol\/L (mean 0.79 \u00b1 0.08 mmol\/L over 9 months). The patient tolerated the infusions well, only developing one minor episode of infusion-related cellulitis. A systematic review of the literature identified 14 reports where subcutaneous magnesium sulfate&lt;sub&gt;&lt;\/sub&gt;was effective and treatment for adults or children with hypomagnesemia was safe. Home-based intermittent administration of subcutaneous magnesium may be a helpful and safe intervention to temporarily prevent and treat select patients with recurrent symptomatic hypomagnesemia.<\/jats:p>","DOI":"10.1159\/000501121","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T21:00:27Z","timestamp":1567458027000},"page":"280-293","source":"Crossref","is-referenced-by-count":13,"title":["Subcutaneous Magnesium Sulfate to Correct High-Output Ileostomy-Induced Hypomagnesemia"],"prefix":"10.1159","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-3278","authenticated-orcid":false,"given":"Mark\u00a0J.","family":"Makowsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Gramlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.091108"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02107.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-6-1301"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2012.21.Sup6.S22"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1994.tb00332.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.1.37"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.09.016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0343"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309861.681"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(15)30412-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2017-001360"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-940080"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2007.0037"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2008.21.4.385"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1908.25310470026002b"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)51313-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(98)90008-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.30643"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/17119.7683"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1037\/a0031037"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:44:39Z","timestamp":1745426679000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,9,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000501121","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.8325794","asserted-by":"subject"}]},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]}}}