{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:28:19Z","timestamp":1783466899756,"version":"3.55.0"},"reference-count":11,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":2394,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction: Distant metastases of papillary thyroid cancers are rare. Most common metastatic sites include bone and lung, whereas metastases to brain, eye, breast, liver, kidney, muscle, and skin are infrequent and almost always appear in advanced-stage tumor disease. Metastases to ovary and\/or uterus are even scarcer. We report herein a very exceptional case of asymptomatic malignant-to-benign tumor-to-tumor metastasis of thyroid origin into a uterine leiomyoma. Case Presentation: We present the case of a 53-year-old female patient who had a previous history of pT1b N0 M0 R0 papillary carcinoma of the lower left thyroid lobe, treated by total thyroidectomy and central lymph node dissection and two successive administrations of radioactive treatment with iodine-131. Six years later, follow-up imaging disclosed an asymptomatic slow-growing 40-mm-long pedicled subserous heterogeneous uterine myoma including a 12-mm hypervascular nodule, which was suspicious for thyroid malignancy on MRI. Discussion: Histopathology of a hysterectomy specimen disclosed a hypervascular well-limited poorly differentiated trabecular carcinomatous infiltration within the uterine leiomyoma. The immunohistochemical profile of the suspicious nodule was compatible with a thyroid origin. Conclusion: A hypervascular \u201chot spot\u201d intramyoma nodule was the diagnostic clue in a clinical context of hematogenous tumor spread of thyroid origin (increased thyroglobulin level).<\/jats:p>","DOI":"10.1159\/000501153","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T17:00:32Z","timestamp":1564506032000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":7,"title":["Myoma Hot Spot: Tumor-to-Tumor Metastasis of Thyroid Origin into Uterine Leiomyoma"],"prefix":"10.1530","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-4467","authenticated-orcid":false,"given":"Anne-Sophie","family":"Bertrand","sequence":"first","affiliation":[{"name":"1Department of Interventional Radiology Imaging, Antoine Lacassagne Cancer Research Center, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Iannessi","sequence":"additional","affiliation":[{"name":"1Department of Interventional Radiology Imaging, Antoine Lacassagne Cancer Research Center, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Peyrottes","sequence":"additional","affiliation":[{"name":"2Department of Anatomopathology, Antoine Lacassagne Cancer Research Center, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Lacout","sequence":"additional","affiliation":[{"name":"3Department of Radiology, Centre m\u00e9dico-chirurgical ELSAN, Aurillac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Thyss","sequence":"additional","affiliation":[{"name":"4Department of Oncology, Antoine Lacassagne Cancer Research Center, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Marcy","sequence":"additional","affiliation":[{"name":"5Department of Interventional Radiology and Diagnostic Imaging, Polyclinique Les Fleurs Groupe ELSAN, Ollioules, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"issue":"11","key":"2026070712593060400_ref1","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1097\/MNM.0000000000000567","article-title":"Efficacy of adjuvant therapy with 3.7\u2009GBq radioactive iodine in intermediate-risk patients with \u2018higher risk features\u2019 and predictive value of postoperative nonstimulated thyroglobulin","volume":"37","author":"Rosario","year":"2016","journal-title":"Nucl Med Commun","ISSN":"https:\/\/id.crossref.org\/issn\/0143-3636","issn-type":"print"},{"issue":"1","key":"2026070712593060400_ref2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12105-010-0236-9","article-title":"Papillary thyroid carcinoma variants","volume":"5","author":"Lloyd","year":"2011","journal-title":"Head Neck Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/1936-055X","issn-type":"print"},{"issue":"1","key":"2026070712593060400_ref3","first-page":"23","article-title":"Papillary thyroid carcinoma with different histological patterns","volume":"34","author":"Lin","year":"2011","journal-title":"Chang Gung Med J","ISSN":"https:\/\/id.crossref.org\/issn\/2309-835X","issn-type":"print"},{"issue":"2","key":"2026070712593060400_ref4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.14791\/btrt.2014.2.2.132","article-title":"Brain Metastases of Papillary Thyroid Carcinoma with Horner\u2019s Syndrome","volume":"2","author":"Cho","year":"2014","journal-title":"Brain Tumor Res Treat","ISSN":"https:\/\/id.crossref.org\/issn\/2288-2405","issn-type":"print"},{"issue":"3","key":"2026070712593060400_ref5","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1677\/erc.1.01210","article-title":"Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour","volume":"13","author":"de la Torre","year":"2006","journal-title":"Endocr Relat Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"1","key":"2026070712593060400_ref6","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1186\/1471-2407-13-551","article-title":"Papillary thyroid carcinoma with massive metastasis in the uterine corpus: a case report","volume":"13","author":"Wang","year":"2013","journal-title":"BMC Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2407","issn-type":"print"},{"issue":"10","key":"2026070712593060400_ref7","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1002\/1097-0142(19821115)50:10[{LT}]2163::AID-CNCR2820501032[{GT}]3.0.CO;2-F","article-title":"Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases","volume":"50","author":"Kumar","year":"1982","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"1","key":"2026070712593060400_ref8","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s13000-014-0193-9","article-title":"Ovarian metastasis from thyroid carcinoma: a case report and literature review","volume":"9","author":"Corrado","year":"2014","journal-title":"Diagn Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/1746-1596","issn-type":"print"},{"issue":"4","key":"2026070712593060400_ref9","doi-asserted-by":"publisher","first-page":"4585","DOI":"10.3892\/ol.2017.6822","article-title":"Metastasis of breast cancer to an endometrial polyp, the cervix and a leiomyoma: A case report and review of the literature","volume":"14","author":"Razia","year":"2017","journal-title":"Oncol Lett","ISSN":"https:\/\/id.crossref.org\/issn\/1792-1074","issn-type":"print"},{"issue":"12","key":"2026070712593060400_ref10","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1097\/00000478-200112000-00002","article-title":"Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior","volume":"25","author":"Nikiforov","year":"2001","journal-title":"Am J Surg Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0147-5185","issn-type":"print"},{"issue":"2","key":"2026070712593060400_ref11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.0001-6349.2005.0255d.x","article-title":"Ectopic thyroid tissue in the uterus","volume":"84","author":"Yilmaz","year":"2005","journal-title":"Acta Obstet Gynecol Scand","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6349","issn-type":"print"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/8\/5\/273\/34753\/etj501153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/8\/5\/273\/34753\/etj501153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:29:38Z","timestamp":1783445378000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/8\/5\/273\/4705\/Myoma-Hot-Spot-Tumor-to-Tumor-Metastasis-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,30]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000501153","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,30]]}}}