{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:34:40Z","timestamp":1772465680501,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We aimed to evaluate the association between Glasgow Coma Scale (GCS) and total homocysteine (tHcy) levels and examine the possible effect modifiers in patients with hemorrhagic stroke. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 1,516 participants with hemorrhagic stroke and having the complete data on baseline GCS and tHcy measurements were included in the final analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The mean (SD) of age, tHcy, and GCS levels were 61.5 (11.3) years, 17.0 (10.3) \u03bcmol\/L, and 13.9 (2.2), respectively. Compared with participants with severe damage (GCS\u00a0&amp;#x3c;9), those with mild damage (GCS \u226513) had significantly lower transformed tHcy levels (\u03b2 = \u20132.46; 95% CI \u20134.80 to \u20130.12). Consistently, a significantly lower transformed tHcy levels were found in participants with mild damage (GCS \u226513; \u03b2 = \u20131.37; 95% CI \u20132.66 to \u20130.08) compared with those with moderate to severe damage (GCS &amp;#x3c;13). In the stratified analysis, a stronger inverse association between GCS categories (\u226513 vs. &amp;#x3c;13) and tHcy concentrations was observed in ever smokers (vs. never; &lt;i&gt;p&lt;\/i&gt; for interaction = 0.045), and in participants with systolic blood pressure (SBP) \u2265160 mm Hg (vs. &amp;#x3c;160 mm Hg; &lt;i&gt;p&lt;\/i&gt; for interaction = 0.031), or total cholesterol (TC) \u22655.2 mmol\/L (vs.\u00a0&amp;#x3c;5.2 mmol\/L; &lt;i&gt;p&lt;\/i&gt; for interaction = 0.025). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; There was an inverse association between GCS level and tHcy concentration among patients with hemorrhagic stroke, especially in ever smokers or in participants with higher SBP or TC levels.<\/jats:p>","DOI":"10.1159\/000501191","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T21:00:31Z","timestamp":1562187631000},"page":"9-15","source":"Crossref","is-referenced-by-count":10,"title":["Association of Glasgow Coma Scale with Total Homocysteine Levels in Patients with Hemorrhagic Stroke"],"prefix":"10.1159","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-5993","authenticated-orcid":false,"given":"Dapeng","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengzhang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houxun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,3]]},"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:45:44Z","timestamp":1745426744000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,18]]},"published-print":{"date-parts":[[2019,9,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000501191","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"8481818","asserted-by":"subject"}]},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}