{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:51:15Z","timestamp":1778655075470,"version":"3.51.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Previous studies have used serum periostin levels as a biomarker of Th2-driven inflammatory responses. However, no population-based study has yet examined the association of serum periostin levels with the allergic status of children. <b><i>Objectives:<\/i><\/b> The aim of this study was to determine the usefulness of periostin as a biomarker for allergy in a group of 7-year-old Korean children. <b><i>Method:<\/i><\/b> This prospective cross-sectional study examined 451 children (aged 7 years to 7 years and 11 months) from the general pediatric population who attended 6 different schools between June and July 2016. A total of 249 children, all of whom completed the questionnaire and skin prick test and provided blood samples, were included in the final analysis. <b><i>Results:<\/i><\/b> The geometric mean serum periostin level was 107.6 ng\/mL (95% CI 104.5\u2013110.7). After adjustment for confounding, serum periostin levels were significantly associated with sensitization to poly-allergens (adjusted odds ratio, aOR 1.032, 95% CI 1.006\u20131.059, <i>p<\/i> = 0.016) and pollen (aOR 1.020, 95% CI 1.002\u20131.039, <i>p<\/i> = 0.026). Serum periostin levels were also associated with eosinophil levels (adjusted \u03b2 = 0.023, SE = 0.009, <i>p<\/i> = 0.010), but were unrelated to body mass index, sex, obesity, or presence of an allergic disease. <b><i>Conclusions:<\/i><\/b> Our results suggest that<b><i><\/i><\/b>serum periostin level may have limited usefulness as a biomarker of allergic disease in children.<\/jats:p>","DOI":"10.1159\/000501224","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T21:02:11Z","timestamp":1569272531000},"page":"195-201","source":"Crossref","is-referenced-by-count":2,"title":["Serum Periostin Level Has Limited Usefulness as a Biomarker for Allergic Disease in 7-Year-Old Children"],"prefix":"10.1159","volume":"180","author":[{"given":"Myongsoon","family":"Sung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hey\u00a0Sung","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u00a0Keon\u00a0","family":"Yon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u00a0Won\u00a0","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u00a0Kyo","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u00a0Suk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u00a0Mi","family":"Jee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn\u00a0Ho","family":"Sheen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Izuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man\u00a0Yong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.11.035"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.025"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.050"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/all.13181"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.033"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12575"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12744"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12943"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12050"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131369"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12622"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12897"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.04.001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2001.16.2.155"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1370\/afm.983"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00059810"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.00993.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000453034"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.12.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.12.006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.11.020"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000053688"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/all.12707"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/all.12599"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12763"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0230-4"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0300-7"}],"container-title":["International 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