{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:19:33Z","timestamp":1777389573200,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The quality of outcome assessment in acne studies has been either subjective\/insufficient or time consuming through the ordinary lesion counting. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To evaluate the application of multimodal clinical imaging (MCI), a combination of imaging technology and computation, in the assessment of acne lesions in a clinical study setting. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A prospective, monocentric, single-group open study designed to evaluate the efficacy and tolerance of a cosmetic product (IP\/SG) in subjects with mild-to-moderate facial acne by classical clinical counting (CCC) \u2013 change in the total\/inflammatory\/noninflammatory acne lesion number compared with baseline (D0) \u2013 Investigator Global Assessment (IGA) and self-reported outcomes. Concomitantly, MCI was administered. The study was performed for 12 weeks (D84) with a 4-week follow-up (D112). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Mean age of patients (&lt;i&gt;n&lt;\/i&gt; = 49) was 18.2 \u00b1 3.7 years (range 13\u201325). The mean acne duration was 3.8 \u00b1 2.8 years. The total number of lesions did not differ significantly between D0\/D84 by both CCC and MCI. However, the Cardiff Acne Disability Index (CADI) and uncomfortable feeling improved at D28\/D0, the perception of oily skin improved at D14\/D0, and the perception of sticky skin improved from D28\/D0 to D56\/D0. Deterioration was detected between D84\/D0 and D112\/D0, namely after product discontinuation. Interestingly, a change in trend was recorded for acne lesions at D14\/D0 by MCI but not by CCC. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; MCI, applied for the first time in a small clinical study setting, is at least as reliable as CCC and may allow for a sensitive longitudinal evaluation of single acne lesions and their response to products, especially in conditions where clinical evaluation reaches its limits.<\/jats:p>","DOI":"10.1159\/000501272","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T21:00:32Z","timestamp":1565211632000},"page":"471-477","source":"Crossref","is-referenced-by-count":4,"title":["Multimodal Clinical Imaging Assessment of the Outcome in Mild-to-Moderate Acne: A Prospective Study"],"prefix":"10.1159","volume":"235","author":[{"given":"Athanassios","family":"Kyrgidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Zampeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Fauger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Sayag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"Christos\u00a0C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.29"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000051771"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12298"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2017.1375636"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15754"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15879"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-014-2853-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120912"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14881"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1718-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14369"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13621"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5141"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00660.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12448"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13882"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90680-5"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:46:33Z","timestamp":1745426793000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,11,8]]},"published-print":{"date-parts":[[2019,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000501272","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.9300983","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}