{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:50:31Z","timestamp":1775616631173,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Care"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; Scalp cooling (SC) offers a chance to reduce hair loss (HL), but patient satisfaction, the effect on well-being, as well as patient selection criteria have not been sufficiently assessed yet. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In the EVAScalp trial, SC was offered to 70 breast cancer patients who received chemotherapy between November 2015 and September 2018. For SC, the Paxman-Orbis-II System was used. Satisfaction was measured by a questionnaire evaluating the level of depression with the WHO-5 well-being index (WHO-5) plus questions addressing the patient\u2019s experiences and side effects using the SC device. To evaluate efficacy, documentation by photo, by a physician, and by an HL-diary was conducted. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Regarding efficacy, a significant difference between chemotherapy regimens is seen. Anthracycline-based therapies led to a stop of SC in 71% of the patients, whereas taxane-based therapies without anthracyclines were associated with a high acceptance of SC, and 88% of patients with paclitaxel-based therapies continued SC throughout their chemotherapy. Overall, only 7.69% of the patients stopped because of side effects. As an indicator for quality of life, WHO-5 was higher (65.8%) in patients with successful SC compared to in patients who stopped SC because of HL or side effects (only 53.0%). The majority of patients (82.22%) with successful SC would recommend SC to other patients. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Patients tolerated SC as long as HL was successfully prevented. The well-being of patients with successful SC was significantly higher than that of patients who stopped SC prematurely. In general, SC is a promising approach and improves patient well-being, but there are still limitations to its utility depending on the chemotherapy regimen used.<\/jats:p>","DOI":"10.1159\/000501393","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T21:00:26Z","timestamp":1564088426000},"page":"171-177","source":"Crossref","is-referenced-by-count":13,"title":["EVA-Scalp: Evaluation of Patient Satisfaction with a Scalp Cooling Device to Prevent Chemotherapy-Induced Alopecia in Breast Cancer Patients"],"prefix":"10.1159","volume":"15","author":[{"given":"Franz-Ferdinand","family":"Bitto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy\u00a0","family":"Phan-Brehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Vallbracht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian\u00a0Gregor","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Schink\u00f6the","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Wolfgarten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Mahner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9744-7372","authenticated-orcid":false,"given":"Nadia","family":"Harbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"W\u00fcrstlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2001.00272.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10630"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e3283409280"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-2081(05)80003-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1374695"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.07.011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)00280-I"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.658966"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2174\/1574887113666181120111104"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-3-500"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.04.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2017.07.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4185-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0342-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.794955"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000376585"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.20939"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.18.00033"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4432-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4983-8"}],"container-title":["Breast Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:41:13Z","timestamp":1745422873000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,23]]},"published-print":{"date-parts":[[2020,5,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000501393","archive":["Portico"],"relation":{},"ISSN":["1661-3791","1661-3805"],"issn-type":[{"value":"1661-3791","type":"print"},{"value":"1661-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]}}}