{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:12:11Z","timestamp":1768266731050,"version":"3.49.0"},"reference-count":48,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Introduction:<\/i><\/b> Regulatory lymphocytes (CD4+ T regulatory cells [Treg], CD8+ Treg, and B regulatory cells [Breg]) play a critical role in immune homeostasis and tolerance. Common variable immunodeficiency (CVID) is associated with increased susceptibility to infections and increased frequency of inflammatory and autoimmune diseases. CD4+ Treg cell abnormalities have been reported in CVID; however, CD8+ Treg cells have not been reported in CVID. The objective of this study was to evaluate CD4+ Treg and CD8+ Treg cells in CVID patients. <b><i>Methods:<\/i><\/b> In 25 patients with CVID and age-matched healthy controls, Treg cells, evaluated in freshly isolated peripheral blood mononuclear cells (natural; nCD4+ Treg and nCD8+ Treg) and following in vitro activation with anti-CD3\/CD28 monoclonal antibodies (induced; iCD4+ Treg and iCD8+ Treg) as well as Breg cells were analyzed with specific monoclonal antibodies and isotype controls using flow cytometry. <b><i>Results:<\/i><\/b> The proportions of nCD4+ Treg (CD4+ CD127<sup>low<\/sup> CD25<sup>high<\/sup> FoxP3+), iCD4+ Treg (CD4+ CD127<sup>low<\/sup> CD25<sup>high<\/sup> FoxP3+), iCD8+ Treg (CD8+ CD25<sup>high<\/sup> CD183+ FoxP3+), and Breg (CD19+ CD24<sup>high<\/sup> CD38<sup>high<\/sup>) lymphocytes were significantly lower in patients with CVID than in controls. <b><i>Conclusions:<\/i><\/b> Altered regulatory lymphocytes may play a role in the pathogenesis and autoimmunity and inflammation associated with CVID.<\/jats:p>","DOI":"10.1159\/000501457","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T21:00:29Z","timestamp":1562619629000},"page":"150-158","source":"Crossref","is-referenced-by-count":20,"title":["Phenotypic Analysis of CD4+ Treg, CD8+ Treg, and Breg Cells in Adult Common Variable Immunodeficiency 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