{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:26:59Z","timestamp":1790803619719,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background:<\/i><\/b> Renal medullary hypoxia precedes the development of acute kidney injury in experimental sepsis and can now be assessed by continuous measurement of urinary oxygen tension (PuO<sub>2<\/sub>). <b><i>Objectives:<\/i><\/b> We aimed to test if PuO<sub>2<\/sub> measurements in patients with septic shock would be similar to those shown in experimental sepsis and would detect changes induced by the administration of furosemide. <b><i>Method:<\/i><\/b> Pilot prospective observational cohort study in a tertiary intensive care unit (ICU). Seven adult patients with septic shock admitted to ICU had PuO<sub>2<\/sub> measurements recorded minutely. There were 29 episodes of intravenous furosemide (20 mg <i>n<\/i> = 19; 40 mg <i>n<\/i> = 10). <b><i>Results:<\/i><\/b> The median pre-furosemide PuO<sub>2<\/sub> was low at 21.2 mm Hg (interquartile range [IQR] 17.73\u201324.86) and increased to 26 mm Hg (IQR 20.27\u201329.95) at 20 min (<i>p<\/i> &#x3c; 0.01), to 27.5 mm Hg (IQR 24.06\u201333.18) at 40 min (<i>p<\/i> &#x3c; 0.01) and to 28.5 mm Hg (IQR 22.65\u201331.03) at 60 min (<i>p<\/i> &#x3c; 0.01). The increase in PuO<sub>2<\/sub> was greater in episodes with a diuretic response &#x3e;2 mL\/kg\/h than during episodes without such a response (<i>p<\/i> &#x3c; 0.01). <b><i>Conclusions:<\/i><\/b> PuO<sub>2<\/sub> measurements in patients are reflective of the low values reported in experimental models of sepsis. PuO<sub>2<\/sub> values increased following furosemide administration with a response independently associated with greater diuresis.<\/jats:p>","DOI":"10.1159\/000501512","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T21:00:26Z","timestamp":1563915626000},"page":"336-345","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock"],"prefix":"10.1159","volume":"48","author":[{"given":"Eduardo\u00a0Atsushi","family":"Osawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore\u00a0Lucio","family":"Cutuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bitker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Canet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cioccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugeesh\u00a0R.","family":"Lankadeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn\u00a0M.","family":"Eastwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger\u00a0G.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive\u00a0N.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinaldo","family":"Bellomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2019,7,23]]},"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/501512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:42:42Z","timestamp":1745422962000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000501512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12,3]]},"published-print":{"date-parts":[[2019,12,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000501512","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}